Extended time-of-flight measurements down to 100 keV at the AMANDE facility with a stilbene scintillator.

The time-of-flight (ToF) method with scintillators is routinely used for determining neutron energy. However, a technical difficulty related to the loss of scintillator efficiency below 1 MeV makes this technique difficult to implement for the energy decade [100 keV-1 MeV]. New crystal production techniques provide stilbene scintillators efficient in this low neutron energy region, making it possible to extend the ToF technique below 1 MeV.

Characterization of CRISPR/Cas9-edited human placental allogenic stromal cells with low tissue factor expression and reduced thrombotic effects.

The tissue factor (TF/CD142) expressed by mesenchymal stromal cells (MSCs) has been regarded as a safety concern in clinical applications as it may trigger thrombosis when MSCs administered intravenously. Human placental allogenic stromal cells (ASCs) are culture-expanded, undifferentiated MSC-like cells derived from full-term postpartum placenta and possess immunomodulatory and pro-angiogenic activities, however, express TF. Here we performed CRISPR/Cas9-mediated TF gene knock out (TFKO) in ASCs, leading to significantly lower TF expression, activity and thrombotic effects.

Tramadol for the Management of Opioid Withdrawal: A Systematic Review of Randomized Clinical Trials.

The increase in the prescription of opioid medications has resulted in a wildfire of misuse of opioids, both for medical and non-medical reasons, with over 1.7 million people in the United States (US) suffering from distinct disorders owing to opioid use. While various medications, such as methadone, buprenorphine, and naloxone, among others, have been used in treating opioid withdrawal symptoms, concerns of the potential abuse of these drugs, the cost of procurement, legislations, and prescription policies have risen.

Clarifying the role of belief-motive explanations in multi-stakeholder realist evaluation.

In realist evaluation, where researchers aim to make program theories explicit, they can encounter competing explanations as to how programs work. Managing explanatory tensions from different sources of evidence in multi-stakeholder projects can challenge external evaluators, especially when access to pertinent data, like client records, is mediated by program stakeholders. In this article, we consider two central questions: how can program stakeholder motives shape a realist evaluation project; and how might realist evaluators respond to stakeholders' belief-motive explanations, including those about program effectiveness, based on factors such as supererogatory commitment or trying together in good faith? Drawing on our realist evaluation of a service reform initiative involving multiple agencies, we describe stakeholder motives at key phases, highlighting a need for tactics and skills that help to manage explanatory tensions.

Scattering matrix of arbitrarily shaped objects: combining finite elements and vector partial waves.

We demonstrate the interest of combining finite element calculations with the vector partial wave formulation (used in T-matrix and Mie theory) in order to characterize the electromagnetic scattering properties of isolated individual scatterers. This method consists of individually feeding the finite element problem with incident vector partial waves in order to numerically determine the T-matrix elements of the scatterer. For a sphere and a spheroid, we demonstrate that this method determines the scattering matrix to high accuracy.

Interplay between spontaneous decay rates and Lamb shifts in open photonic systems.

In this Letter, we describe the modified decay rate and photonic Lamb (frequency) shift of quantum emitters in terms of the resonant states of a neighboring photonic resonator. This description illustrates a fundamental distinction in the behaviors of closed (conservative) and open (dissipative) systems: the Lamb shift is bounded by the emission linewidth in closed systems while it overcomes this limit in open systems.

The Accuracy of Common Hand Injections With and Without Ultrasound: An Anatomical Study.

Background: The aim of the study is to determine the accuracy of hand injections with and without the aid of ultrasound (U/S) into the carpal tunnel, thumb carpometacarpal (CMC) joint, first dorsal compartment (DC) and the radiocarpal (RC) joint.

Methods: Four participants of various level of experience injected the carpal tunnel, thumb CMC, first DC, and RC joint into 40 fresh frozen cadaver specimens with blue dye and radiographic contrast. Participants 1 and 2 were injected without U/S guidance, and participants 3 and 4 were injected with U/S guidance.

A Statewide Child Telepsychiatry Consult System Yields Desired Health System Changes and Savings.

Background: Telepsychiatry has clinical efficacy with children, but questions remain about cost-effectiveness. State agencies and health systems need to know if a child telepsychiatry consult system can address system concerns and improve care quality while lowering costs.

Materials And Methods: To assist care in a rural state with few child and adolescent psychiatrists, an academic center coordinated a consult system of (1) televideo consults for high-needs children with Medicaid and state Multidisciplinary Team (MDT)/foster care involvement, (2) remote medication reviews for beyond guidelines prescribing, and (3) elective community provider telephone-based consults.

Multilevel fast multipole method based on a potential formulation for 3D electromagnetic scattering problems.

A combination of the multilevel fast multipole method (MLFMM) and boundary element method (BEM) can solve large scale photonics problems of arbitrary geometry. Here, MLFMM-BEM algorithm based on a scalar and vector potential formulation, instead of the more conventional electric and magnetic field formulations, is described. The method can deal with multiple lossy or lossless dielectric objects of arbitrary geometry, be they nested, in contact, or dispersed.

Controllable emission of a dipolar source coupled with a magneto-dielectric resonant subwavelength scatterer.

We demonstrate experimentally and theoretically that a local excitation of a single scatterer of relative dielectric permittivity ε = 6 permits to excite broad dipolar and quadrupolar electric and magnetic resonances that shape the emission pattern in an unprecedented way. By suitably positioning the feed with respect to the sphere at a λ/3 distance, this compact antenna is able to spectrally sort the electromagnetic emission either in the forward or in the backward direction, together with a high gain in directivity. Materials with ε = 6 can be found in the whole spectrum of frequencies promising Mie antennas to become an enabling technology in numbers of applications, ranging from quantum single photon sources to telecommunications.

Multipolar effects on the dipolar polarizability of magneto-electric antennas.

We show the important role played by the multipolar coupling between the illuminating field and magneto-electric scatterers even in the small particle limit (λ/10). A general multipolar method is presented which, for the case of planar non centrosymmetric particles, generates a simple expression for the polarizability tensor that directly links the dipolar moment to the incident field. The relevancy of this approach is demonstrated by comparing thoroughly the dipolar moments predicted by the method with full numerical calculations.

Enamel matrix derivative: protein components and osteoinductive properties.

Background: Although enamel matrix derivative (EMD) has demonstrated the ability to promote angiogenesis and osteogenesis both in vitro and in vivo, the specific elements within the EMD compound responsible for these effects remain unknown.

Methods: Nine different protein pools from a commercially produced EMD were collected based on molecular weight. Six of these pools, along with the complete EMD unfractionated compound and positive and negative controls, were tested for their ability to induce bone formation in a calvarial induction assay.

Photonic engineering of hybrid metal-organic chromophores.

An aureate dye: Confined electromagnetic fields in DNA-templated gold nanoparticle dimers were tuned to engineer the fluorescence properties of organic dyes in water (see picture). Purified suspensions of hybrid metal-organic chromophores featured unprecedented photophysical properties, such as a short lifetime and low quantum yield but high brightness.

Boosting the directivity of optical antennas with magnetic and electric dipolar resonant particles.

Dielectric particles supporting both magnetic and electric Mie resonances are shown to be able to either reflect or collect the light emitted by a single photon source. An analytical model accurately predicts the scattering behavior of a single dielectric particle electromagnetically coupled to the electric dipole transition moment of a quantum emitter. We derive near field extensions of the Kerker conditions in order to determine the conditions that strongly reduce scattering in either the forward or backward directions.

Imaging the Gouy phase shift in photonic jets with a wavefront sensor.

A wavefront sensor is used as a direct observation tool to image the Gouy phase shift in photonic nanojets created by micrometer-sized dielectric spheres. The amplitude and phase distributions of light are found in good agreement with a rigorous electromagnetic computation. Interestingly the observed phase shift when travelling through the photonic jet is a combination of the awaited π Gouy shift and a phase shift induced by the bead refraction.

Accelerated single photon emission from dye molecule-driven nanoantennas assembled on DNA.

A photon interacts efficiently with an atom when its frequency corresponds exactly to the energy between two eigenstates. But at the nanoscale, homogeneous and inhomogeneous broadenings strongly hinder the ability of solid-state systems to absorb, scatter or emit light. By compensating the impedance mismatch between visible wavelengths and nanometre-sized objects, optical antennas can enhance light-matter interactions over a broad frequency range.

Takotsubo cardiomyopathy in the setting of acute alcohol withdrawal.

Takotsubo Cardiomyopathy (TCM), also known as stress-induced cardiomyopathy, is a cardiomyopathy characterized by acute reversible apical ventricular dysfunction and apical akinesis in the absence of obstructive coronary artery disease. Although the disease may be precipitated by an acute emotional or physical stressor, the pathophysiology, postulated to involve excess catecholamine release, remains unproven. In contrast, the role of catecholamine excess and hyperadrenergic physiology in acute alcohol withdrawal (AAW) is more established.

Effect of pH on protein distribution in electrospun PVA/BSA composite nanofibers.

We examine the protein distribution within an electrospun polymer nanofiber using polyvinyl alcohol and bovine serum albumin as a model system. We hypothesize that the location of the protein within the nanofiber can be controlled by carefully selecting the pH and the applied polarity of the electric field as the pH affects the net charge on the proteins. Using fluorescently labeled BSA and surface analysis, we observe that the distribution of BSA is affected by the pH of the electrospinning solution.

Necrotizing ulcerative gingivitis: a discussion of four dissimilar presentations.

Background: Necrotizing ulcerative gingivitis (NUG) is a periodontal disease characterized by pain, bleeding, and necrosis of interdental papillae. This series details treatment of four cases, followed by a discussion of the disease.

Case Description: Four patients presented to four practitioners for treatment of severe gingival pain, each eventually being diagnosed with NUG.

Optical and topological characterization of gold nanoparticle dimers linked by a single DNA double strand.

We demonstrate that symmetric or asymmetric gold nanoparticle dimers with substantial scattering cross sections and plasmon coupling can be produced with a perfectly controlled chemical environment and a high purity using a single DNA linker as short as 7 nm. A statistical analysis of the optical properties and morphology of single dimers is performed using darkfield and cryo-electron microscopies. These results, correlated to Mie theory calculations, indicate that the particle dimers are stretched in water by electrostatic interactions.

Crucial role of the emitter-particle distance on the directivity of optical antennas.

We demonstrate that the reflecting properties of a single particle nanoantenna can be extremely sensitive to its distance from a quantum emitter at frequencies lower than the plasmon resonance. The phenomenon is shown to arise from rapid phase variations of the emitter field at short distances associated with a phase of the antenna particle polarizability lower than π/4.

Hafnia alvei pyelonephritis in a renal transplant recipient: case report and review of an under-recognized nosocomial pathogen.

We describe the first case to our knowledge of Hafnia alvei pyelonephritis in a renal transplant recipient. Clinicians should consider this under-recognized pathogen when clinically evaluating immunosuppressed patients with a history of invasive procedures.

Compact metallo-dielectric optical antenna for ultra directional and enhanced radiative emission.

We report the design of highly efficient optical antennas employing a judicious synthesis of metallic and dielectric materials. In the proposed scheme, a pair of metallic coupled nanoparticles permits large enhancements in both excitation strength and radiative decay rates, while a high refractive index dielectric microsphere is employed to efficiently collect light without spoiling the emitter quantum efficiency. Our simulations indicate potential fluorescence rate enhancements of 3 orders of magnitude over the entire optical frequency range.

Microwave measurements of the full amplitude scattering matrix of a complex aggregate: a database for the assessment of light scattering codes.

We present an extensive experimental study of microwave scattering by a fully characterized complex aggregate. We measured the full amplitude scattering matrix (amplitude and phase of the four elements) for a wide range of configurations. The presented results are of special interest to the light scattering community.