Blood troponin levels in acute cardiac events depends on space weather activity components (a correlative study).

Background: Many biological processes are influenced by space weather activity components such as solar activity (SA), geomagnetic activity (GMA) and cosmic ray activity (CRA). Examples are total mortality, acute myocardial infarction (AMI), stroke (cerebrovascular accident), sudden cardiac death, some congenital maladies (congenital heart disease and Down syndrome), many events in neonatology, ophtalmology, blood pressure regulation, blood coagulation, inflammation, etc. The aim of this study was to check if the level of blood troponins (Tns) - markers of myocardial damage and recognized components of modern description of AMI - is connected with the mentioned space weather parameters.

Cosmic ray (neutron) activity and air pollution nanoparticles - cardiovascular disease risk factors - separate or together?

Background: In the last decade, a number of studies were published showing links between cardiovascular events such as stroke (CVA), acute myocardial infarction (AMI), sudden cardiac death (SCD) and cosmic ray activity (CRA) marker neutron activity on the Earth's surface (imp/min). A number of concomitant studies described air pollution fine particles as a similar risk factor. It is not clear which way each of the mentioned factors acts on the way of affecting the human body.

Space weather and human deaths distribution: 25 years' observation (Lithuania, 1989-2013).

Background: Human health is affected by space weather component [solar (SA), geomagnetic (GMA), cosmic ray (CRA) - neutrons, space proton flux] activity levels. The aim of this study was to check possible links between timing of human (both genders) monthly deaths distribution and space weather activity.

Methods: Human deaths distribution in the Republic of Lithuania from 1989 to 2013 (25 years, i.

Considering space weather forces interaction on human health: the equilibrium paradigm in clinical cosmobiology - is it equal?

Background: We are constantly affected by changes in space weather. The principal "players" are solar activity (SA), geomagnetic activity (GMA) and antagonistic to them, cosmic ray activity (CRA) and high energy proton flux. CRA is measured by neutron activity on the earth's surface in imp/min.

Quantification of low-gradient severe aortic stenosis using a hybrid approach combining Doppler echocardiography and thermodilution.

Background And Aim Of The Study: Estimation of stroke volume in the left ventricular outflow tract (LVOT) is a main limitation to aortic valve area (AVA) calculation by echocardiography when using the continuity equation. In this study, the hypothesis was tested that a hybrid method using thermodilution-derived cardiac output measurement and simultaneous Doppler estimation of the systolic ejection period and transvalvular aortic velocities could be used to accurately assess AVA in patients with low-gradient severe aortic stenosis (AS).

Methods: Eighteen patients with low mean gradient (< 40 mmHg) and nine patients with conventionally defined (> or = 40 mmHg) severe AS (< 1 cm2), as assessed by the echocardiographic continuity equation (baseline echocardiography), underwent catheterization and simultaneous Doppler recording of trans-aortic velocities.

[Cardiac arrhythmias and superior vena cava syndrome revealing a Richter's syndrome].

Richter's syndrome is the aggressive transformation of chronic lymphocytic leukemia in a diffuse large cell lymphoma. The locations and the clinical manifestations are varied. We report the case of a Richter's syndrome revealed by cardiac arrhythmias and superior vena cava syndrome in a patient of 78 years followed during 2 years for chronic lymphocytic leukemia.

Association of time of occurrence of electrical heart storms with environmental physical activity.

Aim: Many publications in recent decades have reported a temporal link between medical events and environmental physical activity. The aim of this study was to analyze the time of occurrence of electrical heart storms against levels of cosmological parameters.

Methods: The sample included 82 patients (71 male) with ischemic cardiomyopathy treated with an implantable cardioverter defibrillator at a tertiary medical center in 1999-2012 (5,114 days).

Gene functional dynamics: environment as a trigger?

Recent decades have seen the deciphering of the human genome and, also, progress in studies related to the effects of space-weather on humans. The progress in genetics allows us to connect many human pathologies with specific gene abnormalities. Concomitantly it has been shown that many congenital and adherent diseases, and the timing of death are connected with space factors such as solar activity (SA), geomagnetic activity (GMA), cosmic ray activity (CRA), and space neutron and proton flux.

Birth month and longevity: birth month of victims of sudden (SCD, ≤1 h) and rapid (RCD, ≤24 h) cardiac deaths.

Background: After a publication of a study in the Proceedings of the National Academy of Sciences USA in 2001, we published three studies related to birth month and morbidity of patients that can affect longevity. The aim of this study is to check two groups of cardiac deaths, consisting of more than 50% of cardiovascular mortality in the industrial world, to examine this paradigm.

Methods: Patients suffering rapid cardiac death (RCD) (≤24 h) and sudden cardiac death (SCD) (≤1 h) in Lithuanian Medical Science University hospital, a tertiary 3000-bed facility, in 2000-2010 were studied.

Birth month of patients with malignant neoplasms: links to longevity?

Background: In 2001, the Proceedings of National Academy of Sciences (USA) published a study on the relationship between month of birth and longevity. Subsequent studies revealed differences in month of birth among patients with acute myocardial infarction, a major killer in industrialized countries. The aim of the present study was to analyze month of birth in patients with malignant neoplasms, another major fatal disease.

Acute myocardial infarction (AMI) (n-11026) on days of zero geomagnetic activity (GMA) and the following week: differences at months of maximal and minimal solar activity (SA) in solar cycles 23 and 24.

Background: Acute myocardial infarction (AMI) is one of most common cardiovascular pathologies in the industrial world. In addition to known risk factors, environmental physical activity factors such as solar activity (SA), geomagnetic activity (GMA), and cosmic ray activity (CRA) could be also involved in the timing of AMI. The aim of this study was to study AMI admissions at days of zero GMA, accompanied by high CRA, and the following week in the higher and lowest parts of solar cycles 23 and 24.

Left anterior descending/right coronary artery as culprit arteries in acute myocardial infarction (n=2011) in changing physical environment, percutaneous coronary intervention data, 2000-2010.

Background: Percutaneous coronary intervention (PCI) is one of the principal treatments of acute coronary syndrome (ACS), including acute myocardial infarction (AMI). This treatment largely expanded our knowledge on the pathophysiology of AMI and related coronary pathologies. Recent studies found a significant relationship of the timing of ACS with environmental physical activity: solar (SA), geomagnetic (GMA) and cosmic ray (CRA) activity.

Birth month and longevity - monthly birth distribution in acute coronary events provoked by atherothrombosis in patients treated with percutaneous coronary intervention (PCI).

Background: Human homeostasis is time related. Environmental physical factors also play a role. Recent studies published by the National Academy of Sciences (USA) describe human longevity links with the month of birth.

Physical influences on right ventricular infarction and cardiogenic shock in acute myocardial infarction.

Aim: To determine if complicated acute myocardial infarction (AMI) is related to specific cosmophysical activities.

Methods: The study group included 1170 patients who had undergone primary percutaneous coronary intervention (PCI) for AMI in 2000-2006. Geomagnetic and cosmic ray (neutron) activity (GMA, CRA) on the day of PCI were derived from international observatories.

Traffic accidents and environmental physical activity.

Environmental physical activity (EPA) is considered as one of main regulators of human homeostasis. Evidence is growing that components of this activity through the "human factor" (i.e.

Atherothrombosis: environmental links.

Background: During the past decades, many studies were published considering cosmo-terrestrial influences on different sites of human homeostasis. The aim of this study was to summarize some of those studies in the field of cardiovascular medicine, concentrating on environmental physical activity--Solar (SA), Geomagnetic (GMA), and conversely, Cosmic Ray (CRA)--links with atherothrombosis, the basic mechanism of most vascular catastrophes in modern society.

Methods: A preview of a number of comparative studies between clinical events-acute myocardial infarction (AMI), sudden cardiac death (SCD), stroke (CVA), laboratory data of coagulation, inflammation (daily, monthly), with parameters of SA, GMA, CRA, and closely linked to CRA, high energy space proton flux at high energies.

Timing of life-threatening arrhythmias detected by implantable cardioverter-defibrillators in relation to changes in cosmophysical factors.

Background: Studies have linked the natural history of many pathologies with environmental physical activity. This study investigated the relationship between the occurrence of ventricular tachycardia/fibrillation (VT/VF) recorded by implantable cardioverter defibrillators (ICD) and geomagnetic and cosmic ray (neutron) activity.

Methods: The study group included 85 patients (73 men) with cardiomyopathy (80% ischemic) who underwent ICD placement in the years 1995-2006; 74% had a left ventricular ejection fraction of < 30%.

Congenital heart disease: correlation with fluctuations in cosmophysical activity, 1995-2005.

Background: Environmental physical activity is known to be associated with many factors of human homeostasis, such as fetal development, birth number, and some genetic abnormalities. This study sought to investigate possible temporal links between the occurrence of congenital heart disease and solar, geomagnetic, and cosmic ray activities.

Patients And Methods: The study sample include 79,085 infants born live at a tertiary medical center in central Israel from 1995 to 2005, of whom 1739 were diagnosed with congenital heart disease, including 309 with patent ductus arteriosus (PDA).

Clinical cosmobiology: distribution of deaths during 180 months and cosmophysical activity. The Lithuanian study, 1990-2004. The role of cosmic rays.

Unlabelled: The aim of this study is a next step of our previous, initial, publications--to explore the links between monthly death number (total, and for the major death causes and each gender) with levels of monthly cosmophysical activity in a long-term, big cohort observation.

Methods: Death number during 180 consecutive months from the National Registry of Lithuania for years 1990-2004 were studied. A total of 630,205 deaths were analyzed (333,035 males).