[Structure and antiviral activity of adamantane-containing polymer preparation].

New water-soluble antiviral chemical agents, containing 10 to 30% of adamantane derivatives (amino-, aminopropyl-adamantane-, aminomethyl- and rimantadine), which were conjugated with polycarboxylic matrixes of the divinyl ether and maleic anhydride copolymers (DIVEMA), were developed. The polymeric drugs exhibited a low cytotoxicity (4 to 10 times less than rimantadine) and a wide spectrum of antiviral activity against influenza viruses, including both the remantadine-resistant strains of A/PR/8/34 (H1N1) and the B/Saint-Petersburg strain/71/77 as well as against herpes viruses of type 1, parainfluenza viruses of types 1 and 3 and RS-virus. A reduction of the viral infection titer in their reproduction in sensitive cells' cultures was more than 2.

[Effect of lipophilic derivatives of a divinyl ether-maleic anhydride copolymer on immunocompetent cells].

A series of lipophilic derivatives of the copolymer divinyl ether with maleic anhydride were synthesized and tested for their effects on immunocompetent cells. Increases in the length of a hydrophobic moiety and its quantity in the polymer chain of the agent were demonstrated to substantially modify the factors of animals' humoral and cell-mediated immunity. This phenomena is well associated with the examined superficial qualities of solutions of the agents and their mycelium forming capacity.

[Antiviral and immunostimulating effect of maleic anhydride copolymers in experimental neuroviral infections].

The virus-inhibiting and immunostimulating activity of Soviet preparations, maleic anhydride copolymers, was demonstrated in alpha-, flavi-, and bunyavirus infections. Positive results were obtained in subcutaneous and intraperitoneal inoculations of the preparations used in prophylactic and therapeutic-prophylactic schedules. Stimulation of vaccination immunity was observed after combined use of copolymers and the vaccine against Eastern equine encephalomyelitis.