[Combined inhibiting action of new salicylic acid derivatives with alpha-tocopherol of the oxidation of methyl oleate].

The inhibitory action of compositions of alpha-tocopherol (alpha-TP) and salicylic acid derivatives on the process of initiated oxidation of methyl oleate (MO), alpha-TP and the salicilyc acid derivatives exhibited the synergistic affect, which was demonstrated by the methods of UV-spectroscopy and high-performance liquid chromatography (HPLC).

[Kinetics and action mechanism of vitamin D3 in the process of lipid and blood plasma oxidation in model system].

Kinetics and mechanism of vitamin D3 action were investigated in the process of initiated oxidation of various modeling systems in comparison with activity of various antioxidants such as: alpha-tocopherol, dibunol, alpha-tocopheryl quinone, ubiquinone Q10, philloquinone and beta-carotene. Vitamin D3 addition increased initial and maximal rates of oxygen consumption. The length of circuits, value of a kinetic parameter k2/square root k6, describing oxidability of system as a whole was also increased.

[The interrelation of chemical structure and inhibiting action of the stericly hindered phenols of ichfan groups].

Inhibitory action of spatially hindered phenol antioxidants (AO) of ICHFAN groups, phenosan derivatives, containing ethanolamine, substituted by N- alkyl substituents R3 containing various carbon chains (from C2 to C 16) was investigated using two models, initiated oxidation of the homogenous methyl oleate (MO) solution in chlorbenzene, and a water-emulsive medium containing sodium dodecyl sulphate. ICHFANs act via two mechanisms: they react with peroxide radicals with the reaction rate constant of k7 = (0.59-1.

[Intermolecular interactions of dipeptide triterpene derivatives and natural quinones with alpha-tocopherol].

In modeling system of the initiated oxidation of methyl oleate the antioxidation activity of a series of dipeptide derivatives of betulonic and glycyrrhetic acids, natural quinones (ubiquinone, philloquinone and menadione) and the kinetic effects of their combined action with alpha-tocopherol were studied. The same extreme character of the dependence of inhibitory action on the concentration of all investigated substances was found. Combined addition of triterpenoids or quinones together with alpha-tocopherol attenuated their effect.

[Antioxidant effect of novel probucol analogs and their combinations with alpha-tocopherol].

The antioxidant and antiradical activities of sulfur containing phenols which are analogues of probucol in comparison with alpha-tocopherol and BHT were tested using initiated methyl oleate oxidation model. The antioxidant effect linearly increased with increasing concentration of phenols. The ability of investigated phenols to destroy and reduced accumulation of hydroperoxides is revealed.

[Inhibiting effects of mixtures of alpha-tocopherol with beta-carotene or vitamin A during oxidation of polyunsaturated fatty acid esters].

The inhibitory activities of individual natural antioxdants (AOs), such as alpha-tocopherol (I), beta-carotene (II), vitamin A(III) and their mixtures were comparatively studied when oxidation of microbial polyunsaturated fatty acid esters that predominately contain ethyl arachidonate was initiated; effects of antagonism were found in the combined action of I and II, I and III. The magnitude of antagonism effect was estimated from the difference between the total additive effects of individual AOs and the experimentally determined effects of their mixture. There is a U-dependence of changes in the antagonism values upon II concentrations at steady-state I levels.

[Antioxidant activity of natural and synthetic quinones].

Antioxidation activity (AOA) of ubiquinone (Q10), phylloquinone (vitamin K1), menadione as well as of the newly synthesized analogues of vitamin K1--N-derivatives of 2-methyl-3-aminomethyl 1.4-naphthoquinone, producing autocomplexes with intramolecular transfer of electrons, was studied in the model system of the methyl oleate initiated oxidation. The menadione AOA was shown to be 2-fold higher as compared with the inhibitory activity of natural quinones.

[Effects of synergism during combined antioxidant action of phosphatidylcholine with natural and synthetic quinones].

The combined action of ovarian phosphatidylcholine and phylloquinone (vitamin K1), menadione, artificial analogues of vitamin K1--N-derivatives of 2-methyl-3-aminomethyl-1,4-naphthoquinone (AK-40, AK-49) recommended as promising membrane protectors was studied. Synergic effects were detected in the antioxidant action of the quinones studied and phosphatidylcholine; AK-40 was the most effective in the presence of phosphatidylcholine. The synergic effect correlated with the concentrations of the antioxidants.

[Synergistic effect of antioxidants and phospholipids during oxidation of natural lipids].

The effect of mixtures of phospholipids (PL) and natural antioxidants (AO)--tocopherol (TP), ubiquinone, ubichromenol, vitamin K, on the value of induction periods and on the rate of initiated oxidation of model substrates (++methyl oleate, mixtures of fatty acid methyl ethers, ethylbenzene) was studied at 60 degrees C. The possibility of synergism of different AO in the presence of PL has been established. It has been shown that the action of bioantioxidants in lipids may be increased 2.

[The study of the additive antioxidative activity of total natural lipid antioxidants].

Kinetics of methyl oleate and ethylbenzene oxidation was studied in presence of tocopherol homologues alpha, beta, gamma, delta, tocopherol derivatives C6 and C11, ubichinol QH2-9, which were isolated from natural lipids. Effects of various natural antioxidants in mixtures were interindependent.

[Relation between activity of antioxidants and oxidation of substrates in natural lipids].

Using chemiluminescence method, the oxidation level of lipids extracted from various organs and tissues of fish Coregonus peled (Gmelin) was investigated. The analysis of interrelation between the oxidation level, quantity and composition of phospholipids (PL), fatty acids (FA), natural antioxidants (NAO) was carried out. The oxidation level of the lipids under investigation is shown to increase in series: first go internal fat lipids, then--lipids of brain, white muscles, immature eggs, red muscles, liver.

[Study of total activity of natural lipid antioxidants by chemiluminescence method].

The total antiradical activity of lipid antioxidants extracted from organs and tissues of fish Coregonus peled (Gmelin) was investigated using chemiluminescence method. It has been established that lipids contain antioxidants of two types. The bioantioxidants of the first type have a comparatively high efficiency constant K7eff.

[Mechanism of the antioxidant activity of lipids].

The manometric method was used to study antioxidant activity of lipids, alpha-tocopherol, phospholipids and their mixtures. Antioxidant activity of the components under study was demonstrated to account for 10-60% of the total antioxidant activity of lipids.