Gain-managed nonlinear amplification of ultra-long mode-locked fiber laser.

In this study, we explored the gain-managed nonlinear (GMN) amplification of ultra-low repetition rate pulses in the range of less than 1 MHz. By seeding the developed 1040 nm ultralong fiber modelocked laser to the GMN amplifier, we achieved high gain and boosted the nonlinear pulse propagation effects. We demonstrated that GMN amplification of low repetition rate pulses provided amplification exceeding 32 dB and spectral broadening up to 91 nm at relatively low pump power levels.

Resonantly induced mitigation of supermode noise in a harmonically mode-locked fiber laser: revealing the underlying mechanisms.

We have performed experimental and numerical studies enabling clear insight into the physical mechanisms underlying the super-mode noise mitigation in harmonically mode-locked (HML) fiber lasers using the resonant continuous wave (CW) injection. New experiments have refined the requirements to the positions inside the laser spectrum assigned to the injected CW component, a Kelly sideband, and the transparency peaks of the birefringent fiber filter. In particular, we have proved experimentally that the noise mitigation effect is dominating with the CW injected to the long-wavelength side of laser spectrum.

Mitigation of the supermode noise in a harmonically mode-locked ring fiber laser using optical injection.

We report on a new, to the best of our knowledge, technique enabling mitigation of the supermode noise (and timing jitter) in a soliton harmonically mode-locked (HML) fiber laser built on the nonlinear polarization evolution (NPE). An optical injection of an external continuous wave (CW) into the HML laser cavity results in an increase of the supermode noise suppression level (SSL) by a two-three order of magnitude for harmonics between 25th and 135th. The operation mechanism involves phase-locking between the injected light and soliton pulses and exhibits strong resonant dependence on the CW laser wavelength.

Pulse repetition rate tuning of a harmonically mode-locked ring fiber laser using resonant optical injection.

We report on a new, to the best of our knowledge, technique enabling fine-tuning of the pulse repetition rate (PRR) of a soliton harmonically mode-locked (HML) fiber laser built on the nonlinear polarization evolution (NPE). Optical injection of an external continuous wave (CW) into the HML laser cavity is used for this purpose enabling precise PRR tuning with the elementary step equal to the fundamental PRR one-by-one. The effect exhibits strong resonance dependence on the CW laser wavelength and available in both positive and negative directions.

All-fiber polarization-maintaining mode-locked laser operated at 980 nm.

For the first time, to the best of our knowledge, we present an all-fiber polarization-maintaining passively mode-locked picosecond laser operated at 980 nm. The laser cavity had a ring configuration with a semiconductor saturable absorber mirror as a mode-locking element. As an active medium, we used a specially designed cladding-pumped Yb-doped fiber with reduced cladding-to-core diameter ratio.

Author Correction: The light-oxygen effect in biological cells enhanced by highly localized surface plasmon-polaritons.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

The light-oxygen effect in biological cells enhanced by highly localized surface plasmon-polaritons.

Here at the first time we suggested that the surface plasmon-polariton phenomenon which it is well described in metallic nanostructures could also be used for explanation of the unexpectedly strong oxidative effects of the low-intensity laser irradiation in living matters (cells, tissues, organism). We demonstrated that the narrow-band laser emitting at 1265 nm could generate significant amount of the reactive oxygen species (ROS) in both HCT116 and CHO-K1 cell cultures. Such cellular ROS effects could be explained through the generation of highly localized plasmon-polaritons on the surface of mitochondrial crista.

Anti-inflammatory and cell proliferative effect of the 1270 nm laser irradiation on the BALB/c nude mouse model involves activation of the cell antioxidant system.

Recently, many interdisciplinary community researchers have focused their efforts on study of the low-level light irradiation effects (photobiomodulation, PBM) as a promising therapeutic technology. Among the priorities, a search of new wavelength ranges of laser radiation to enhance the laser prospects in treatment of autoimmune and cancer diseases commonly accompanied by disorders in the antioxidant system of the body. The laser wavelengths within 1265-1270 nm corresponds to the maximum oxygen absorption band.

[Use of current radiation techniques in the diagnosis and treatment of juvenile angiofibromas of the nasopharynx].

In 1992-2001 seventeen patients with juvenile nasopharyngeal angiofibromas (JNAs) were treated at Krasnoyarsk Territorial Clinical Hospital. The patients underwent a comprehensive diagnosis involving computed tomography (CT), magnetic resonance imaging (MRI), and angiography, followed by tumor vascular embolization. Later on JNAs were surgically removed in 14 patients, a course of radiation therapy was performed.

[The joint use of hemosorption and plasmapheresis in the combined treatment of rheumatoid arthritis patients].

Aim: Assessment of hemopheresis effects on calcium-regulating and immune systems, clinical and laboratory activity of rheumatoid arthritis (RA).

Materials And Methods: Hemosorption and plasmapheresis were included in combined treatment of 86 RA patients. Plasmapheresis was performed 3-5 days after hemosorption (a total of 4-6 procedures per course).