Publications by authors named "Stoian Alexandru"
Exploring Costimulatory Blockade-Based Immunologic Strategies in Transplantation: Are They a Promising Immunomodulatory Approach for Organ and Vascularized Composite Allotransplantation?
J Pers Med
March 2024
Article Synopsis
- The field of transplantation has advanced significantly since the first hand transplant in 1998, particularly in vascularized composite allotransplantation (VCA), which faces challenges like the need for lifelong immunosuppressive therapy.
- Current research aims to improve immunosuppressive strategies to reduce toxicity and foster donor-specific tolerance, emphasizing the role of costimulatory signals in T cell activation.
- This review summarizes data on costimulatory blockade as a potential method to prevent organ rejection and enhance the success of VCA, exploring new techniques for safer transplantation procedures.
Background: Rectal cancer is one of the most common malignant pathologies worldwide. Currently, the standard treatment of this pathology consists of radio-chemotherapy followed by low anterior resection with total mesorectal excision or abdominoperineal proctectomy for medium/low rectal cancer.
Objectives: In recent years, another treatment strategy has been proposed, stemming from the finding that up to 40% of patients receiving neoadjuvant treatment had a complete pathological response.
Treatment of tibial defects with important soft tissue involvement after bilateral lower limb trauma are challenging for both orthopedic and plastic surgeons. Several therapeutic options are described in armamentarium of reconstructive surgeons such as bone grafts, bone substitutes, distractions osteogenesis, limb prosthesis, free flaps, negative pressure therapy and unfortunately amputation. We describe a patient with tibial and soft tissue defect reconstructed using a chimeric flap composed of latissimus dorsi, serratus anterior muscle and two ribs.
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