Publications by authors named "Stohnii Y"
Article Synopsis
- Fibrinogen is a complex plasma protein with αC-domains crucial for processes like blood clot formation, platelet aggregation, and cell interactions.
- Specific truncated forms of fibrinogen were created to study the roles of its N-terminal and C-terminal sub-domains.
- Results showed that both sub-domains contribute to fibrin polymerization and platelet aggregation, with the N-terminal being more influential in aggregation and the C-terminal significantly impacting cell viability and cancer cell migration.
NMDA receptor expression during cell transformation process at early stages of liver cancer in rodent models.
Am J Physiol Gastrointest Liver Physiol
January 2022
Article Synopsis
- Hepatocellular carcinoma (HCC) is a common type of liver cancer that is resistant to traditional treatments, leading to a need for effective screening methods for early detection.
- The study aimed to investigate whether subunits of the -methyl-D-aspartate receptor (NMDAR) could be used as biomarkers to identify precancerous liver conditions in rats with varying stages of liver fibrosis.
- Results showed that NMDAR subunits, particularly NR1 and NR2B, emerged during severe liver fibrosis and HCC progression, indicating their potential as new biomarkers for early detection and monitoring of liver cancer development.