Voltage-dependent G-protein regulation of Ca2.2 (N-type) channels.

How G proteins inhibit N-type, voltage-gated, calcium-selective channels (Ca2.2) during presynaptic inhibition is a decades-old question. G proteins Gβγ bind to intracellular Ca2.

Electrical and G-protein Regulation of CaV2.2 (N-type) Channels.

How G-proteins inhibit N-type, voltage-gated, calcium-selective channels (Ca 2.2) during presynaptic inhibition is a decades-old question. G-proteins Gβγ bind to intracellular Ca 2.

Release of the type I secreted alpha-haemolysin via outer membrane vesicles from Escherichia coli.

The alpha-haemolysin is an important virulence factor commonly expressed by extraintestinal pathogenic Escherichia coli. The secretion of the alpha-haemolysin is mediated by the type I secretion system and the toxin reaches the extracellular space without the formation of periplasmic intermediates presumably in a soluble form. Surprisingly, we found that a fraction of this type I secreted protein is located within outer membrane vesicles (OMVs) that are released by the bacteria.