Publications by authors named "Stijn Van Laarhoven"
Introduction: Pathological response of pancreatic ductal adenocarcinoma (PDAC) to neoadjuvant chemotherapy (NAT) has been associated with oncological outcome. The aim of the study was to investigate factors associated with favourable tumour regression in patients undergoing pancreatic resection for PDAC.
Methods: Patients who received NAT before undergoing PDAC resection at two institutions were reviewed.
Article Synopsis
- Intraductal oncocytic papillary neoplasms (IOPNs) are now identified as distinct from intraductal papillary mucinous neoplasms (IPMNs), with limited information on their recurrence and survival outcomes.
- A study analyzed outcomes of 415 patients with invasive IOPNs and adenocarcinoma from IPMN over a median of 6 years, finding similar recurrence rates between invasive IOPNs and ductal A-IPMN, but poorer survival compared to colloid A-IPMN.
- The research concluded that invasive IOPNs behave like aggressive cancers, with adjuvant chemotherapy showing no significant impact on recurrence rates in any of the studied cancer types.
Article Synopsis
- The study examines the outcomes of different precursor epithelial subtypes of adenocarcinoma from intraductal papillary mucinous neoplasms (A-IPMN), focusing on clinical features and recurrence patterns among patients who underwent pancreatic surgery.
- A total of 297 patients were analyzed, revealing that gastric, pancreatobiliary, and mixed subtypes have similar outcomes that are worse than the intestinal subtype in terms of recurrence and overall survival.
- The research found that adjuvant chemotherapy specifically improved survival rates in the pancreatobiliary subtype, but not in gastric, intestinal, or mixed subtypes, indicating a potential area for further exploration in treatment strategies.
Article Synopsis
- - The study investigates factors affecting long-term survival and recurrence in patients with adenocarcinoma from intraductal papillary mucinous neoplasms, focusing on those who had pancreatic resection between 2010 and 2017 in Europe and Asia.
- - It analyzed data from 288 patients, revealing that 48% experienced recurrence within about 98 months, with 35% remaining disease-free at the 5-year mark.
- - Key negative predictors for long-term disease-free survival included multivisceral resection, tumor location in the pancreatic tail, poor differentiation, lymphovascular invasion, and perineural invasion, leading to the development of a predictive model with a good success rate.
Article Synopsis
- A study was conducted to determine the effects of adjuvant chemotherapy on patients with adenocarcinoma from intraductal papillary mucinous neoplasia after surgical resection, analyzing data from 459 patients across 18 centers between 2010 and 2020.
- The results showed that 59.9% of patients received various chemotherapy regimens, but there was no significant difference in recurrence rates or survival outcomes between those who received chemotherapy and those who did not.
- Overall, the study concluded that adjuvant chemotherapy does not appear to improve recurrence patterns or survival rates in this patient population.
Article Synopsis
- The study aimed to compare long-term cancer outcomes between patients with adenocarcinoma from intraductal papillary mucinous neoplasms (A-IPMN) and pancreatic ductal adenocarcinoma (PDAC) after surgical resection.
- Data revealed that A-IPMN patients generally had better survival rates and lower recurrence rates compared to PDAC patients, including longer median survival (39.0 months for A-IPMN vs. 19.5 months for PDAC).
- While A-IPMN showed higher rates of peritoneal and lung recurrence, PDAC had more locoregional recurrences, but overall, systemic recurrence rates were similar between the two groups.
Article Synopsis
- The study investigates recurrence patterns and treatment outcomes following pancreatic surgery for adenocarcinoma originating from intraductal papillary mucinous neoplasms (IPMN), involving 459 patients from multiple centers between 2010 and 2020.
- Recurrences were seen in 45.5% of patients, with a significant portion occurring within the first year, while the type of treatment did not significantly affect recurrence rates or survival based on location of the recurrence.
- Overall survival improved for patients receiving additional treatment post-recurrence, with a median survival of 27.0 months compared to 14.6 months without further treatment.
Importance: Understanding the learning curve of a new complex surgical technique helps to reduce potential patient harm. Current series on the learning curve of minimally invasive distal pancreatectomy (MIDP) are mostly small, single-center series, thus providing limited data.
Objective: To evaluate the length of pooled learning curves of MIDP in experienced centers.
Purpose: A preoperative estimate of the risk of malignancy for intraductal papillary mucinous neoplasms (IPMN) is important. The present study carries out an external validation of the Shin score in a European multicenter cohort.
Methods: An observational multicenter European study from 2010 to 2015.
Article Synopsis
- The study focused on evaluating the best achievable outcomes in minimally invasive distal pancreatectomy with splenectomy (MIDPS) using the Achievable Benchmark of Care (ABC™) method.
- A retrospective analysis was conducted involving 1,595 patients across 31 European centers from 2003 to 2019, assessing key clinical outcomes such as conversion rates and morbidity.
- Key findings revealed low benchmarks for conversion (2.5%) and severe morbidity (8.4%), with risk factors identified for both severe complications and conversion during surgery, suggesting these benchmarks can guide future improvements in patient care standards.
Background: Adequate fluid resuscitation is paramount in the management of acute pancreatitis (AP). The aim of this study is to assess benefits and harms of fluid therapy protocols in patients with AP.
Methods: MEDLINE, Embase, Science Citation Index and clinical trial registries were searched for randomised clinical trials published before May 2020, assessing types of fluids, routes and rates of administration.
A 51-year-old man developed burn wounds on both knees after finishing a cement floor. Cement burns are caused by wet cement, which is highly alkaline Initial treatment consists of lavage. Further management can be conservative but in full thickness injuries excision and grafting should be considered.
View Article and Find Full Text PDFBackground: Early hepatic artery thrombosis (eHAT) after liver transplantation occurs in 3% of adults and 8% of children and often results in retransplantation. eHAT is initially asymptomatic and arterial patency is monitored with percutaneous Doppler ultrasound screening (pDUS). The aim of the study is to analyze the diagnostic accuracy of "continuous" Doppler registration (CONDOR) using an implantable miniature Doppler.
View Article and Find Full Text PDFHepatoblastoma and liver metastasis of Wilms' tumors are rare hepatic tumors in children. Treatment of both tumors consists of a combination of chemotherapy and liver surgery. Radiofrequency ablation (RFA) is frequently used for the treatment of adult liver tumors but is rarely mentioned as a treatment option in pediatric liver tumors.
View Article and Find Full Text PDF[New guideline on acute appendicitis: routine preoperative imaging is too simple].
Ned Tijdschr Geneeskd
June 2010
With 16,000 operations every year, acute appendicitis is one of the most common surgical diagnoses in Dutch emergency rooms. Diagnosis is based on clinical features: history, physical examination and laboratory testing. When the diagnosis is made, surgeons tend to operate quickly to prevent complications.
View Article and Find Full Text PDFBackground & Aims: The advent of targeted therapies in hepatocellular carcinoma (HCC) has underscored the importance of pathway characterization to identify novel molecular targets for treatment. We evaluated mTOR signaling in human HCC, as well as the antitumoral effect of a dual-level blockade of the mTOR pathway.
Methods: The mTOR pathway was assessed using integrated data from mutation analysis (direct sequencing), DNA copy number changes (SNP-array), messenger RNA levels (quantitative reverse-transcription polymerase chain reaction and gene expression microarray), and protein activation (immunostaining) in 351 human samples [HCC (n = 314) and nontumoral tissue (n = 37)].