Publications by authors named "Stijn Kremer"
Introduction: Extracranial vascular characteristics determine the accessibility of the large vessel intracranial occlusion for endovascular treatment (EVT) in acute ischemic stroke. We developed and validated a prediction model for failure of the transfemoral approach to aid clinical decision-making regarding EVT.
Methods: A prediction model was developed from data of patients included in the Dutch multicenter MR CLEAN Registry (March 18, 2014, until June 15, 2016) with penalized logistic regression.
Glioblastoma is associated with a poor prognosis. Even though survival statistics are well-described at the population level, it remains challenging to predict the prognosis of an individual patient despite the increasing number of prognostic models. The aim of this study is to systematically review the literature on prognostic modeling in glioblastoma patients.
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- Glioblastoma has a median survival of 15 months, prompting the need for new treatment strategies; this study reviews the impact of beta-blockers on glioma growth based on existing literature.* -
- The systematic search yielded 10 preclinical studies and 1 clinical study, revealing that beta-blockers may reduce glioma cell proliferation, migration, and enhance drug sensitivity, though results on migration were inconsistent.* -
- While preclinical evidence suggests potential mechanisms for beta-blockers against glioma, the single clinical study found no survival benefit, highlighting the need for further research to determine their effectiveness in clinical outcomes.*
Objective: Several studies have shown that patients admitted with an acute myocardial infarction during the weekends have a higher mortality rate than those admitted during weekdays, possibly attributable to less trained personnel available and a lower use of medical procedures. The current study aimed to assess this ‘weekend-effect’ in a nationwide registry.
Methods: In the Netherlands, all inhabitants are, by law, obliged to have health insurance and all claim data are centrally registered.