Prevalence of frailty and pre-frailty in patients with rheumatoid arthritis: a systematic literature review and meta-analysis.

Objectives: Frailty is a common geriatric syndrome and is characterised by a decreased physiological reserve and increased vulnerability to stressors. Pre-frailty is a risk-state before frailty. A systematic literature review (SLR) and meta-analysis was conducted to: (1) estimate the prevalence of (pre-)frailty in RA patients; (2) explore whether variation in instruments influences (pre-)frailty prevalence.