Efficacy of mast cell directed therapies in irritable bowel syndrome: a systematic review.

Background And Study Aim: Lately, mast cells (MCs) are increasingly implicated in the pathophysiology of irritable bowel syndrome (IBS). The aim of this systematic review was to assess the efficacy of mast cell directed therapies in reducing the main symptoms of IBS: abdominal pain and changes in stool frequency or consistency.

Patients And Methods: Pubmed, Web of Science and Scopus were searched until December 19, 2022.