syrinx formation in a patient with type I Chiari malformation: Case report and review of the literature.

This report highlights the case of a 56-year-old woman with an incidental type I Chiari malformation who on initial presentation had no associated cervical syrinx on magnetic resonance imaging (MRI), but who on subsequent MRI 8 years later was found to have developed a upper cervical cord syrinx.

Identification of mesenchymal stem cells in perinodular fat and skin in Dupuytren's disease: a potential source of myofibroblasts with implications for pathogenesis and therapy.

Dupuytren's disease (DD) is a fibroproliferative disorder characterized by aberrant proliferation of myofibroblasts, the source of which remains unknown. Recent studies indicate that circulating and tissue-resident mesenchymal stem cells (MSCs) can differentiate into myofibroblasts. Therefore, the aim of this study was to profile MSCs from phenotypically distinct DD sites including cord, nodule, skin overlying nodule (SON), and perinodular fat (PNF) compared with unaffected internal controls, that is, distant palmar fat (DPF) and transverse palmar fascia (Skoog's fibers) as well as external control carpal tunnel (CT) tissue including skin, fat, and fascia.

Metastatic implantation squamous cell carcinoma in a split-thickness skin graft donor site.

We present the case of a patient who developed a possible implantation metastatic squamous cell carcinoma (SCC) at a donor site 2 months following split-thickness skin graft (STSG) harvesting. This case highlights implantation of malignant cells from a contaminated hollow needle as a mechanism of spread to skin graft donor sites and offers an important learning point in the practice of local anaesthetic cutaneous cancer surgery.

Abdominal constriction band: A rare location for amniotic band syndrome.

Amniotic band syndrome refers to the uncommon occurrence of a variety of congenital deformities, most probably due to foetal entanglement in strands ruptured from the amniotic sac. We present a rare case of an abdominal constriction band together with a short literature review.

Dupuytren's diathesis revisited: Evaluation of prognostic indicators for risk of disease recurrence.

Purpose: The term diathesis relates to certain features of Dupuytren's disease (DD) and dictates an aggressive course of disease. The initial description of DD diathesis included 4 factors: (1) ethnicity, (2) family history, (3) bilateral DD, and (4) ectopic lesions (DD outside the palm). The degree of diathesis is considered important in predicting recurrence and extension of DD after surgical management.

The heritability of Dupuytren's disease: familial aggregation and its clinical significance.

Purpose: Dupuytren's disease (DD) is a benign, fibroproliferative disease affecting the hands. The familial occurrence of DD and its presence in identical twins suggests a genetic basis for the condition. Our aims in this study were (1) to provide evidence for familial aggregation of DD by estimating the sibling recurrence-risk ratio and (2) to link previously associated environmental risk factors with family history of DD.

Giant cell tumour of tendon sheath in a child: a case report.

Giant cell tumour of the tendon sheath is uncommon in children. We describe this tumour arising from the right ring finger in an eight-year-old girl. Plane radiographs showed a soft tissue mass with erosion of the distal phalanx.

Musculotendinous anomalies in musician and nonmusician hands.

Musculoskeletal abnormalities of musicians' hands and upper extremities are well-recognized and potentially career-threatening problems. Of the many types of potentiality problematic musculoskeletal disorders that could be assessed, this study focused on joint instability and musculotendinous anomalies. For this study, the hands of 92 music students were compared with the hands of 64 nonmusician control subjects.

Genetic susceptibility to dupuytren disease: association of Zf9 transcription factor gene.

Transforming growth factor beta 1 (TGF-beta 1) is a key fibrogenic cytokine that has been shown to stimulate fibroblast proliferation and extracellular matrix deposition and has been implicated in the pathogenesis of Dupuytren disease. Zf9 is a transcription factor that increases TGF-beta 1 expression in tissue. The authors previously demonstrated a lack of association between common TGF-beta 1 and TGF-beta 2 polymorphisms and Dupuytren disease.