Publications by authors named "Stewart A Lonky"
Objective: To measure the depth of sampling of the uterine ectocervix with the use of a stiff-bristled, spiral-shaped brush (SpiraBrush Cx; Trylon Corporation, Torrance, CA).
Materials And Methods: Eligible hysterectomy specimens were identified. The ectocervix was brushed with an inked SpiraBrush Cx in four quadrants with either light (gentle) or heavy (forceful) pressure.
Objective: To compare a new spiral-shaped tissue-sampling brush with a standard cervical punch biopsy.
Methods: Before large loop excision of the transformation zone, women with cervical intraepithelial neoplasia underwent a transepithelial brush biopsy of a portion of a colposcopically identified lesion, followed by a punch biopsy of the remaining portion. Brush biopsy samples were processed using liquid-based cytology and cell block techniques.
Article Synopsis
- E-cadherin is crucial for cell adhesion in normal cervical tissue and its presence at different epithelial layers correlates with Papanicolaou smear results in cervical dysplasia.
- In a study of 25 women with cervical dysplasia, E-cadherin was found throughout all epithelial layers in 10 of 11 women with normal smears, indicating potential false negatives.
- The findings suggest that abnormal persistence of E-cadherin may hinder the exfoliation of abnormal cells, impacting smear accuracy.