Publications by authors named "Stevie L Muscarella"
Article Synopsis
- The study explored how immune responses, metabolism, and sleep are interconnected in mice with non-metastatic mammary cancer, focusing on the role of interleukin-6 (IL-6) and its effects.
- Tumor-bearing mice exhibited increased hunger, decreased leptin levels, and heightened sensitivity to ghrelin, with inflammation from IL-6 present but not entirely responsible for metabolic and sleep issues.
- By investigating specific brain neurons linked to metabolism and sleep, researchers found that blocking certain receptors improved metabolic health and sleep quality, highlighting the significance of neural signals in cancer-related metabolic changes.
Breast cancer survivors are more likely to develop mood disorders and cognitive deficits than women in the general population. Previous studies suggest that peripheral tumors elicit central pro-inflammatory cytokine production, in turn leading to depression and cognitive deficits. In the current study, two cohorts of female Balb/C mice received bilateral orthotopic injections of syngeneic 67NR, 4T07, or 4T1cells (1 × 10 cells per injection) to induce mammary tumors.
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