Publications by authors named "Steven W"

Extranodal marginal zone lymphoma (EMZL) is a low-grade subtype of B-cell non-Hodgkin lymphoma that can affect any mucosal tissue, most commonly the GI tract. Primary involvement of the breast, known as primary breast lymphoma (PBL), is a very rare manifestation. We report an unusual case of a 65-year-old woman with primary breast EMZL presenting as calcifications discovered during screening mammography.

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Objective: To study the effects of the three methods and three-acupoint technique on DRG gene expression in SNI model rats and to elucidate the molecular mechanism of the three methods and three-acupoint technique on promoting recovery in peripheral nerve injury.

Methods: 27 male SD rats were randomly divided into three groups: a Sham group, the SNI group, and the Tuina group. The Tuina group was treated with a tuina manipulation simulator to simulate massage on points, controlling for both quality and quantity.

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Tuina is a traditional Chinese treatment for sensory disturbances caused by peripheral nerve injury and related diseases. Our previous studies showed that tuina regulates relevant regions and indices of the spinal dorsal horn using the , , and method in (BL37), (GB34), and (BL40). Treatment prevents muscle atrophy, protects spinal cord neurons, and promotes sciatic nerve repair.

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Reason For Performing Study: The proximal metacarpal region is a common site of origin of lameness in the performance horse. A number of disease entities are recognised as causes of proximal metacarpal lameness but a definitive diagnosis is often elusive. Magnetic resonance imaging (MRI) is hypothesised to offer advantages over traditional imaging modalities in the investigation of proximal metacarpal pain.

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The deleterious effects of maternal ethanol consumption on neonatal immune development and early immune responses has been well documented. However, the effects of such neonatal exposure to maternally consumed ethanol on the neonates' immune responses in their adult life, especially in combination with additional ethanol exposure, has received little attention. For these experiments, female rats were fed on either 6% ethanol or pair-fed isocaloric control Lieber-DeCarli liquid diets for 30 days prior to, and during, pregnancy and lactation.

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Article Synopsis
  • The study investigated how maternal alcohol consumption affects the immune response of rat pups to the parasite Trichinella spiralis during different developmental phases.
  • Rats were divided into four groups based on the timing of ethanol exposure, and pups were later immunized and challenged to assess their immune responses.
  • Results showed that pups exposed to maternal ethanol during early pregnancy and lactation had higher parasite counts and lower antibody levels, indicating weakened immunity compared to control pups.
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Maternal ethanol consumption in rats has been shown to inhibit lactational transfer of immunity to Trichinella spiralis (T. spiralis) from dams to their neonates. The purpose of this study was to determine if this depressed immune transfer could be altered by treating the dams with a known immunostimulatory drug during pregnancy and lactation.

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Article Synopsis
  • Maternal ingestion of ethanol during pregnancy and lactation can negatively impact the transfer of immunity against the intestinal parasite Trichinella spiralis to nursing pups.
  • In the study, rat mothers were either fed ethanol or a control diet before and after being infected with the parasite, and their pups' immune responses were measured.
  • Pups from ethanol-treated mothers showed significantly higher intestinal worm counts compared to controls, particularly when the mothers consumed ethanol prior to infection, indicating reduced immunity in the offspring.
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  • The study investigates how T lymphocytes contribute to maternal-to-neonatal immunity during breastfeeding, specifically examining their presence in the mammary gland under normal and infection-stimulated conditions.
  • It was found that T cell numbers peak during late pregnancy but significantly decline during early lactation, suggesting that some T cells may be transferred into the milk for the neonate's immunity.
  • In cases of maternal infection (specifically with Trichinella spiralis), a notable decrease in T cells was observed in the mammary tissue during early lactation, hinting at a greater loss of T cells to milk compared to non-infected controls.
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Significant immunological protection is provided to the newborn by the transfer of maternal leukocytes during nursing. The objective of this study was to determine if ethanol ingestion altered the distribution of T, B and accessory cells in the mammary glands of normal rats or in rats infected with Trichinella spiralis (T. spiralis).

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We have previously demonstrated the maternal-to-neonatal transfer of immunity to T. spiralis during lactation and have shown that antigen-specific T lymphocytes, when injected into the mother or orally fed to neonates, can mediate this transfer. To further analyze the T cell subsets involved in conferring this protection, T lymphocytes were isolated from the mesenteric lymph nodes of syngeneic donor rats infected 4-6 days earlier with T.

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The effects of ethanol ingestion on immune responses of female rats against Trichinella spiralis (T. spiralis) infections were investigated. Female rats were pair-fed either ethanol-containing or isocaloric control liquid diets for 68 days, during which time they underwent one pregnancy cycle.

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The potential of maternally derived cellular factors to mediate immunity to Trichinella spiralis in neonates during lactation was investigated in this study. Female FI rats, infected with T. spiralis, were able to transfer immunity to their suckling offspring, evidenced by a significant reduction in the intestinal parasite burdens of their neonates.

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Morphometric procedures were used to quantitate changes induced by ethanol in tissue components of rat mammary gland. Rats were pair-fed ethanol-containing or isocaloric control liquid diets formulated for pregnant or lactating animals, or maintained on regular laboratory chow. Short term animals were pair-fed ethanol or control diets from Day 1 of pregnancy through lactation Days 2 or 10.

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Although sheep erythrocytes (SRBCs) are extensively used as an antigen in immunological studies, their histological distribution in lymphoid tissues has received little attention. The objective of this study was to determine the histological distribution of injected SRBCs in rat spleen. SRBCs were labelled with fluorescein isothiocyanate (FITC) to facilitate their identification in spleen sections with fluorescence microscopy.

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The spleens of two species of voles were studied to determine the relationship between arterial terminals, macrophages and antibody-mediated erythrocyte receptors. The vascular distribution was studied by vascular injections and by use of PAS-stained serial sections. Macrophages were identified by their positive metalophil and hydrolytic enzyme reactions and their ability to phagocytose carbon.

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In order to identify the initial site of antibody formation in rat spleen, an investigation was made to determine the effects of different antigen dosages on the localization of specific antibodies against sheep erythrocytes (SRBCs). Sixty rats were intravenously injected with 1 ml of either 1%, 5%, or 10% suspensions of SRBCs and killed at days 1, 2, 3, and 4 after immunization. A tissue agglutination procedure in which the binding of SRBCs to cryostat sections of spleen was used to localized anti-SRBC antibodies.

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In 25 calves an atrio-ventriculo-aortic bypass was performed and the metabolism and the regulation of coronary blood flow during stepped assistance of the left ventricle was studied. With mean aortic blood pressure kept constant stepped decrease in left ventricular pressure from 120 to 0 mmHg diminished myocardial oxygen consumption from 7.7 to 1.

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The effects of the estrogenic compounds, diethylstilbestrol (DS) and diethylstilbestrol dophosphate (DSP) on morphologically demonstrable characteristics of reticuloendothelial (RE) cells were studied in rat spleen. These included metalophilia, acid phosphatase, nonspecific esterase and phagocytosis. Routine histological and histochemical techniques were used to determine the distribution of metalophilic cells, hydrolytic enzymes, the presence of intracytoplasmic PAS-positive material, hemosiderin sequestration, and the ability to phagocytose injected carbon particles and bacterial organisms.

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