Myelin water fraction estimation using small-tip fast recovery MRI.

Purpose: To demonstrate the feasibility of an optimized set of small-tip fast recovery (STFR) MRI scans for rapidly estimating myelin water fraction (MWF) in the brain.

Methods: We optimized a set of STFR scans to minimize the Cramér-Rao Lower Bound of MWF estimates. We evaluated the RMSE of MWF estimates from the optimized scans in simulation.