Gender-specific Single Transcript Level Atlas of Vasopressin and its Receptor (AVPR1a) in the Mouse Brain.

Vasopressin (AVP), a nonapeptide synthesized predominantly by magnocellular hypothalamic neurons, is conveyed to the posterior pituitary the pituitary stalk, where AVP is secreted into the circulation. Known to regulate blood pressure and water homeostasis, it also modulates diverse social behaviors, such as pair-bonding, social recognition and cognition in mammals including humans. Importantly, AVP modulates social behaviors in a gender-specific manner, perhaps, due to gender differences in the distribution in the brain of AVP and its main receptor AVPR1a.

Microaggressions in European versus American Workplace Environments of Otolaryngology-Head and Neck Surgery.

Objective: To compare the workplace experience of European and U.S. members of the otolaryngology community.

Laryngeal Trauma.

Laryngeal trauma is rare but potentially fatal. Initial evaluation includes efficient history and physical examination, imaging, bedside flexible laryngoscopy, and if necessary, operative endoscopic evaluation. Multiple classification systems exist for laryngeal trauma, and each has its merits.

Workplace Environment Microaggressions in Otolaryngology-Head and Neck Surgery: An International Survey.

Objective: To survey members of the otolaryngology community about their personal and observed experiences of being treated differently because of one's physical attributes, cultural norms, or preferences in the workplace.

Study Design: Cross-sectional survey.

Setting: International Electronic Survey.

Prevalence of Laryngopharyngeal Reflux Symptoms, Dysphonia, and Vocal Tract Discomfort in Amateur Choir Singers.

Introduction: Vocal tract discomfort (VTD), dysphonia, and laryngopharyngeal reflux (LPR) symptoms are complaints frequently reported by amateur singers. There are two aims of this study. The first is to evaluate the prevalence of these symptoms using validated questionnaires.

Trauma-informed care improves management of paradoxical vocal fold movement patients.

Objectives: Vocal cord dysfunction (VCD) has been used by clinicians, primarily pulmonologists, to describe a variety of conditions in which the regulation and coordination of vocal fold movements are part of the explanation of cough or difficulty breathing, mainly paradoxical vocal fold motion disorder (PVFM). Prior studies show an intersection of mental health issues, primarily anxiety, and PVFM. We began incorporating mental health screening tools using the Life Events Checklist-5 (LEC-5) and the Posttraumatic Stress Disorder (PTSD) Checklist for Civilians (PCL-C) to assess symptomatology that may be related to traumatic life events.

Heterogeneity in gut microbiota drive polyphenol metabolism that influences α-synuclein misfolding and toxicity.

The intestinal microbiota actively converts dietary flavanols into phenolic acids, some of which are bioavailable in vivo and may promote resilience to select neurological disorders by interfering with key pathologic mechanisms. Since every person harbors a unique set of gut bacteria, we investigated the influence of the gut microbiota's interpersonal heterogeneity on the production and bioavailability of flavonoid metabolites that may interfere with the misfolding of alpha (α)-synuclein, a process that plays a central role in Parkinson's disease and other α-synucleinopathies. We generated two experimental groups of humanized gnotobiotic mice with compositionally diverse gut bacteria and orally treated the mice with a flavanol-rich preparation (FRP).

Climatically driven changes in primary production propagate through trophic levels.

Climate and land-use change are the major drivers of global biodiversity loss. Their effects are particularly acute for wide-ranging consumers, but little is known about how these factors interact to affect the abundance of large carnivores and their herbivore prey. We analyzed population densities of a primary and secondary consumer (mule deer, Odocoileus hemionus, and mountain lion, Puma concolor) across a climatic gradient in western North America by combining satellite-based maps of plant productivity with estimates of animal abundance and foraging area derived from Global Positioning Systems telemetry data (GPS).

Dietary polyphenols promote resilience against sleep deprivation-induced cognitive impairment by activating protein translation.

Previous evidence has suggested that dietary supplementation with a bioactive dietary polyphenol preparation (BDPP) rescues impairment of hippocampus-dependent memory in a mouse model of sleep deprivation (SD). In the current study, we extend our previous evidence and demonstrate that a mechanism by which dietary BDPP protects against SD-mediated cognitive impairment is via mechanisms that involve phosphorylation of the mammalian target of rapamycin complex 1 and its direct downstream targets, including the eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1) and the ribosomal protein S6 kinase β-1 (p70S6K). In additional mechanistic studies in vitro, we identified the brain bioavailable phenolic metabolites derived from the metabolism of dietary BDPP that are responsible for the attenuation of SD-mediated memory impairments.

Speyeria (Lepidoptera: Nymphalidae) Conservation.

(Nymphalidae) are a conspicuous component of the North American butterfly fauna. There are approximately 16 species and >100 associated subspecies (or geographical variants). are univoltine, occupy a wide range of habitats, overwinter as first instar larvae, and feed only on native violets.

Comparative Analysis of Characteristics of Voice Use Amidst Clergy.

The development of "Care of the Professional Voice" as a subspecialty of Otolaryngology-Head and Neck Surgery has expanded the concept of professional voice users. Although sometimes uncompensated, the clergy represents a unique group of voice users who are required to perform at a professional level. Additionally, cultural norms create great diversity in terms of style of delivery and typical venues, adding to the interest in this subset of professional voice users.

Topical and vapor toxicity of saturated fatty acids to the German cockroach (Dictyoptera: Blattellidae).

Topical and fumigant toxicity of saturated aliphatic fatty acids with chain lengths of C1 through C14 were determined against the German cockroach, Blattella germanica (L.). In the C1 to C11 series, topical toxicity (LD50 in milligram per adult male) ranged from 0.

Functional endoscopic analysis of beatbox performers.

Objectives: Beatboxing is a form of vocal percussion in which performers imitate drum sounds, interspersed with vocalization and other sounds, using their vocal tracts. Although similarities between beatboxing and singing are expected because of the anatomy involved, the medical literature has a wealth of information on singing and minimal studies on beatboxing. The objective of our study was to report on a case series of functional endoscopic evaluation of the anatomy involved in beatboxing and determine whether beatboxing may be a risk factor for phonotrauma or if this form of vocalization might be protective of the vocal folds.

Efficacy of commercial baits and new active ingredients against firebrats and silverfish (Zygentoma: Lepismatidae).

Commercial baits containing boric acid, hydramethynon, and indoxacarb were tested against the firebrat, Thermobia domestica (Packard), and silverfish, Lepisma saccharina L. (both Zygentoma: Lepismatidae), under laboratory conditions. Three boric acid baits were consumed in significantly smaller amounts than untreated control food and did not effectively control either species.

OTA highlight paper predicting future displacement of nonoperatively managed lateral compression sacral fractures: can it be done?

Purpose: This study was designed to assess the rate of displacement in nondisplaced sacral fractures and to determine if certain fracture patterns are more prone to future displacement.

Design: Retrospective.

Setting: Two Level I trauma centers.

Comparative toxicity and repellency of microencapsulated and other liquid insecticide formulations to the German cockroach (Dictyoptera: Blattellidae).

Responses of German cockroaches, Blattella germanica (L.) (Dictyoptera: Blattellidae), to microencapsulated (ME) formulations of six insecticides (bifenthrin, chlorpyrifos, cyfluthrin, deltamethrin, lambda-cyhalothrin, and permethrin) were compared with emulsifiable concentrates (EC) (chlorpyrifos, cyfluthrin, deltamethrin, and permethrin) or ready-to-use (RTU) formulations (bifenthin and lambda-cyhalothrin). Two rates were tested per comparison.