Cellular Infiltrate in Rheumatoid Arthritis-associated Paracentral Corneal Ulceration.

Purpose: To investigate an immunopathogenesis of central and paracentral corneal ulceration associated with rheumatoid arthritis.

Methods: Sparse infiltrating cells in the ulcer area were identified by immunohistochemistry applied to archived formalin fixed, paraffin embedded tissues that had been recovered from patients undergoing penetrating keratoplasty necessitated by rheumatoid-associated central or paracentral corneal ulceration.

Results: Clinically, the ulcers presented as non-infiltrated lesions with a modicum of other ocular inflammation.