Gut Metabolism of Furanocoumarins: Proposed Function of Co -Methyltransferase.

Gut metabolism of natural products is of great interest due to the altered biological activity of the metabolites. To study the gut metabolism of the dietary furanocoumarins, the biotransformation of was studied with human gut microbiota. The major components of , including xanthotoxin (), bergapten (), imperatorin (), isoimperatorin (), oxypeucedanin (), and byakangelicol (), were all metabolized by the human fecal sample, and each furanocoumarin was also biotransformed by sp.