Impact of T and N stage and treatment on survival and relapse in adjuvant rectal cancer: a pooled analysis.

Purpose: To determine survival and relapse rates by T and N stage and treatment method in five randomized phase III North American rectal adjuvant studies.

Patients And Methods: Data were pooled from 3,791 eligible patients enrolled onto North Central Cancer Treatment Group (NCCTG) 79-47-51, NCCTG 86-47-51, US Gastrointestinal Intergroup 0114, National Surgical Adjuvant Breast and Bowel Project (NSABP) R01, and NSABP R02. Surgery alone (S) was the treatment arm in 179 patients.

Impact of T and N substage on survival and disease relapse in adjuvant rectal cancer: a pooled analysis.

Purpose: To determine the rates of survival and disease control by TNM and MAC stage in three randomized North American rectal adjuvant studies.

Materials And Methods: Data were merged from 2551 eligible patients on NCCTG 79-47-51 (n = 200), NCCTG 86-47-51 (n = 656), and INT 114 (n = 1695). All patients received postoperative radiation, and 96% were randomized to receive concomitant and maintenance chemotherapy.