External validation of NTCP-models for radiation pneumonitis in lung cancer patients treated with chemoradiotherapy.

Purpose: Normal tissue complication probability (NTCP) models can be used to estimate the risk of radiation pneumonitis (RP). The aim of this study was to externally validate the most frequently used prediction models for RP, i.e.

[Referred with the working diagnosis 'pneumothorax: could it be another diagnosis?].

Background: Patients who are referred to an emergency department (ED) often have a working diagnosis. Hospital physicians may be inclined to accept this diagnosis and incorrectly link the findings of investigations to it. This may lead to an incorrect definitive diagnosis and therapy.

An instrument dedicated for modelling of pulmonary radiotherapy.

Background And Purpose: Radiotherapy plays a pivotal role in lung cancer treatment. Selection of patients for new (radio)therapeutic options aiming at improving outcomes requires reliable and validated prediction models. We present the implementation of a prospective platform for evaluation and development of lung radiotherapy (proPED-LUNG) as an instrument enabling multidimensional predictive modelling.

Reticular basement membrane in asthma and COPD: similar thickness, yet different composition.

Background: Reticular basement membrane (RBM) thickening has been variably associated with asthma and chronic obstructive pulmonary disease (COPD). Even if RBM thickness is similar in both diseases, its composition might still differ.

Objective: To assess whether RBM thickness and composition differ between asthma and COPD.