Publications by authors named "Steven Petrovski"
Arthritis Rheumatol
January 2025
Article Synopsis
- Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis, and the study investigates the role of soluble CD13 (sCD13) and its signaling through the bradykinin receptor B1 (B1R) in SSc pathogenesis.
- Researchers found elevated levels of CD13, B1R, and MMP14 in skin from SSc patients, which contributed to fibrosis through signaling pathways activated by TGF-β and sCD13.
- The study concludes that targeting the sCD13-B1R axis could represent a novel and effective therapeutic strategy for treating skin fibrosis in SSc.
