Publications by authors named "Steven Nistico"

Lipids play an essential role in skin barrier health. With age, there is a natural reduction of physiological lipids such as fatty acids, ceramides, and cholesterol. The triple lipid restore cream is a moisturizer that contains an optimized lipid ratio for aging skin.

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  • IgE-mediated food allergies involve a type 1 immune response triggered by certain foods, resulting in a variety of symptoms that can vary in severity, including severe reactions like anaphylactic shock.
  • This pilot study examined the effects of dupilumab, an antibody treatment approved for atopic dermatitis, on patients with both AD and food allergies, focusing on their allergic sensitization profiles.
  • Results indicated a significant reduction in specific IgE levels and molecular allergen components after 16 weeks of dupilumab treatment, suggesting potential benefits in managing allergic symptoms among patients with multiple sensitivities.
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  • * The systematic literature review analyzed six relevant studies from a total of 64, examining the effectiveness of these treatments on nine patients, highlighting benefits like long-term tissue remodeling and improved skin aesthetics.
  • * The findings suggest that the combination of laser therapy and fillers could enhance treatment for LS patients, indicating a need for more research to develop a solid clinical approach and improve patient quality of life.
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  • The emergence of biotechnological drugs has transformed the treatment of moderate-to-severe atopic dermatitis (AD), focusing on anti-interleukin (IL)-13 therapies.
  • A systematic review highlighted tralokinumab's effectiveness and safety, showing significant improvements in various clinical metrics for patients inadequately managed by previous therapies.
  • While tralokinumab has demonstrated promising results and a favorable safety profile, more extensive studies are needed to confirm its long-term benefits compared to existing treatments.
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The prevalence of skin aging and the request for effective treatments have driven dermatological research towards natural solutions. This study investigates the anti-aging efficacy of two bioactive natural polyphenols, Oleocanthal and Oleacein, in a skincare formulation. A single-blind, randomized clinical trial involved 70 participants, using a comprehensive exclusion criterion to ensure participant safety and study integrity.

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Cellulite, or edemato-fibro-sclerotic panniculopathy (EFP), is characterized by dermal and hypodermal changes leading to adipose tissue accumulation and compromised venous circulation. This study investigates the efficacy of a hypertonic cream containing concentrated sodium chloride (Jovita Osmocell) in addressing water retention and structural alterations in adipose tissue, aiming to interrupt the cellulite formation process. A 12-week, prospective, monocentric, double-blind, placebo-controlled study enrolled 30 female subjects with grade II or III cellulite.

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  • Melasma is a common skin condition that's hard to treat, and assessing the depth and distribution of pigmentation is crucial for effective treatment.
  • Non-invasive imaging techniques like reflectance confocal microscopy (RCM) are helping to evaluate melasma by providing detailed insights into pigment location within the skin layers.
  • The study highlights two main types of melasma (epidermal and mixed) and emphasizes RCM's role in monitoring treatment effectiveness and identifying factors that influence treatment outcomes.
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: Acne scars are one of the most disturbing and long-term symptoms of acne vulgaris, having a negative impact on a person's physical, emotional, and social well-being. : the purpose of the study was to evaluate the efficacy and post-treatment outcomes of a dual-wavelength system combining the irradiation of two wavelengths at 10,600 nm and 1540 nm in the management of facial atrophic acne scars. : Four healthy adult volunteers aged 24-53 years were enrolled.

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  • - A new 675-nm wavelength red light laser technology is being studied for its effectiveness and safety in treating skin conditions, particularly focusing on skin aging, melasma, and acne scars.
  • - A literature review was conducted using various databases, including PubMed and Google Scholar, up until March 2023 to gather relevant studies on this laser treatment.
  • - While the results of different studies showed some variability, all indicated positive clinical outcomes, suggesting that the 675-nm laser system is a promising option for addressing various skin disorders.
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: For nearly 15 years, carbon dioxide (CO) laser has been the gold standard in skin rejuvenation. Aim: The purpose of this study was to assess the efficacy of a new laser device which combines CO and 1540 nm wavelengths in wrinkles reduction, using a recently developed scanning unit named the µScan DOT scanner. : A total of 20 female patients underwent from two to four laser treatment sessions performed once every 45-90 days.

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Laser treatments have become popular in Dermatology. In parallel to technologic development enabling the availability of different laser wavelengths, non-invasive skin imaging techniques, such as reflectance confocal microscopy (RCM), have been used to explore morphologic and qualitative skin characteristics. Specifically, RCM can be applied to cosmetically sensitive skin areas such as the face, without the need for skin biopsies.

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In this report the use of eye cosmetic products and procedures and how this represents a lifestyle challenge that may exacerbate or promote the development of ocular surface and adnexal disease is discussed. Multiple aspects of eye cosmetics are addressed, including their history and market value, psychological and social impacts, possible problems associated with cosmetic ingredients, products, and procedures, and regulations for eye cosmetic use. In addition, a systematic review that critically appraises randomized controlled trial evidence concerning the ocular effects of eyelash growth products is included.

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Background: Vitiligo is an autoimmune dermatological disease characterized by hypopigmented macules. Treatments include topical agents, phototherapy, and laser therapies. Different lasers should be individually chosen regarding location, extent, activity of the disease.

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  • - Fractional ablative (10,600 nm) and non-ablative (1540 nm) lasers can be combined in a sequential treatment to enhance skin rejuvenation, reduce downtime, and improve cosmetic outcomes compared to using either laser alone.
  • - In a study using ex vivo sheep skin, researchers tested different irradiation conditions with both laser types, revealing that the combination maintains the ablative characteristics of the 10,600 nm laser while enhancing thermal effects.
  • - The findings suggest that using this dual-wavelength approach not only improves the depth of skin lesions but also increases the coverage area, offering promising implications for future therapeutic skin treatments.
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: Hair removal is a common cosmetic problem interesting more and more patients nowadays. Various laser treatments are currently available. Alexandrite and Nd:YAG laser are the most effective procedures in lighter and darker skin phototypes, respectively.

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Asian patients with Fitzpatrick skin type III-IV are a less studied subtype of patients in the medical literature. Q-Switched, 1064 nm neodymium-doped yttrium aluminum garnet (Nd: YAG) laser with a fractionated beam profile (QSF) is a new modality that was reported to be effective in the treatment of scars. This study aims to evaluate the efficacy and safety of QSF Nd: YAG laser in treating scars in Asian patients.

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Basal cell carcinoma (BCC) is the most frequently occurring type of all cancers, and represents 80% of all skin cancer. The estimated lifetime risk for BCC in the white population is between 33% and 39% for men and 23% and 28% for women. Its incidence doubles every 25 years and is increasing in the young population.

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Background: Although mood disorders have been well characterized in Immune-mediated inflammatory diseases, physical function and satisfaction in social roles have not yet been defined as independent domains.

Objective: The study aims to assess satisfaction in social roles and physical function alterations in an Immune-mediated inflammatory diseases population and identify associated characteristics.

Methods: Physical function and social roles satisfaction were evaluated through the Patient-Reported Outcomes Measurement System.

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Facial telangiectasias are dilated blood vessels that can represent a cosmetic issue for patients. They may be associated with other conditions, such as rosacea. Laser and light treatments are nowadays becoming a cornerstone in the management of these lesions.

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Prurigo nodularis (PN) is a dermatological condition characterized by nodular hyperkeratotic lesions mainly on the legs and arms. Asymmetrical PN is a rare dermatological condition often associated with paralysis and stroke. In this paper, we present the case of a 77-year-old woman who developed post-ictal PN which responded to dupilumab, an anti-interleukin-4/13 drug approved for the management of AD, with an extreme reduction in itch sensation.

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Background: A healthy lifestyle is not always able to improve the abdomen’s appearance, especially in those patients who have undergone sudden weight changes. Objective: We aimed at evaluating the efficacy of combined microwaves and flat magnetic stimulation (FMS) to treat abdominal localized adiposity and laxity. Methods: Twenty-five patients were subjected to two treatment sessions per month on the abdominal area with microwaves.

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A large part of the world’s population suffers from Striae distensae (SD) or stretch marks, which create physical and psychological discomfort in people. We evaluate the SD clinical improvement by using a non-ablative fractional Nd:YAP 1340 nm laser. The research was performed on 25 patients of both sexes, with a mean age of 31 ± 13.

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