Publications by authors named "Steven M Noles"
Article Synopsis
- IGF-I plays a crucial role in muscle growth and repair by promoting satellite cell function, reducing inflammation, and enhancing fiber formation.
- Research utilized CRISPR-Cas9 to modify IGF-I in mice, revealing that non-glycosylated forms (3RA) had more IGF-I but slower muscle regeneration post-injury, while glycosylated forms (2ND) showed improved regeneration despite lower IGF-I levels.
- The study highlights that glycosylation is important for IGF-I storage, but cleavage is essential for its effective use during growth and muscle repair after injury.
