Imaging approach to COVID-19 associated pulmonary embolism.

The novel coronavirus disease-2019 (COVID-19) illness and deaths, caused by the severe acute respiratory syndrome coronavirus-2, continue to increase. Multiple reports highlight the thromboembolic complications, such as pulmonary embolism (PE), in COVID-19. Imaging plays an essential role in the diagnosis and management of COVID-19 patients with PE.

Performance of a Severity Score on Admission Chest Radiography in Predicting Clinical Outcomes in Hospitalized Patients With Coronavirus Disease (COVID-19).

Chest radiographs (CXRs) are typically obtained early in patients admitted with coronavirus disease (COVID-19) and may help guide prognosis and initial management decisions. The purpose of this study was to assess the performance of an admission CXR severity scoring system in predicting hospital outcomes in patients admitted with COVID-19. This retrospective study included 240 patients (142 men, 98 women; median age, 65 [range, 50-80] years) admitted to the hospital from March 16 to April 13, 2020, with COVID-19 confirmed by real-time reverse-transcriptase polymerase chain reaction who underwent chest radiography within 24 hours of admission.

The Impact of Spinal Cord Stimulation on Sleep Patterns.

Background: Studies of chronic pain show sleep disturbances to be a prevalent symptom in 50-88% of patients and studies show improved pain to correspond with improved sleep. The impact of spinal cord stimulation (SCS) on sleep in failed back surgery syndrome, complex regional pain syndrome, and neuropathic pain patients has not been studied prospectively.

Objectives: We prospectively assess the impact of SCS on sleep quality using the Insomnia Severity Index (ISI) and Epworth Sleepiness Scale (ESS).

Pedometry as an External Measure of Spinal Cord Stimulation Patient Outcomes.

Background: Chronic pain is a debilitating biologic and psychologic condition which affects nearly one third of the American population with an annual cost of $560 to $635 billion from associated health care costs and lost productivity. Treatment of chronic pain is difficult to objectively evaluate as it relies on subjective measure. An objective measure would be beneficial in assessing treatment efficacy and towards developing a closed loop system.

A Prospective Study of the Intra- and Postoperative Efficacy of Intraoperative Neuromonitoring in Spinal Cord Stimulation.

Background: Accurate lead placement is critical for spinal cord stimulation (SCS) efficacy. The traditional gold standard of awake placement is often technically difficult. While there is retrospective evidence supporting the use of intraoperative neurophysiological monitoring (IOM) as an alternative, a prospective assessment has not yet been performed.

Predictors of Spinal Cord Stimulation Success.

Introduction: As many as 30% of spinal cord stimulation (SCS) patients fail to obtain long-term pain coverage, even with the strictest parameters of a successful trial, unremarkable psychological assessment, and ideal placement of the permanent device. Why these patients either never receive adequate benefit or lose benefit remains elusive.

Methods: We perform a retrospective review of our prospective database of SCS patients undergoing surgery for routine indications.

Biomimetic aryl hydroxylation derived from alkyl hydroperoxide at a nonheme iron center. Evidence for an Fe(IV)=O oxidant.

Many nonheme iron-dependent enzymes activate dioxygen to catalyze hydroxylations of arene substrates. Key features of this chemistry have been developed from complexes of a family of tetradentate tripodal ligands obtained by modification of tris(2-pyridylmethyl)amine (TPA) with single alpha-arene substituents. These included the following: -C(6)H(5) (i.

Peripheral Palladium(II) and Platinum(II) Complexes of Bis(dimethylamino)porphyrazine.

The unsymmetrical porphyrazine (tetraazaporphyrin) bearing a single peripheral bis(dimethylamino) functionality, Mg[pz(NMe(2))(2)(Pr)(6)], was prepared by base-catalyzed cross condensation of dipropyl maleonitrile (in excess) with dimethylamino maleonitrile. The freebase (2H[pz(NMe(2))(2)(Pr)(6)]) and centrally metalated forms (M[pz(NMe(2))(2)(Pr)(6)]; M = Ni(II), Cu(II), Mn(III)) were prepared by treatment of Mg[pz(NMe(2))(2)(Pr)(6)] with trifluoroacetic acid and then the appropriate metal salt. PdCl(2) and PtCl(2) were coordinated to the peripheral bis(dimethylamino) chelates, yielding the bimetallic complexes, M[pz(NMe(2))(2)(Pr)(6)]M'Cl(2) (M = Ni, Cu; M' = Pd, Pt).