Publications by authors named "Steven K Leckie"
Study Design: Independent retrospective review of prospectively collected data, comparative cohort study.
Objective: The objective of this study was to compare the clinical, radiographical, and cost/value of the addition of an interbody arthrodesis (IBA) to a posterolateral arthrodesis (PLA) in the surgical treatment of L4-L5 degenerative spondylolisthesis (DS). The authors hypothesized that the addition of IBA to PLA would produce added value while incurring minimal additional costs.
Article Synopsis
- Patients with intervertebral disc degeneration (IDD) may benefit from injected human umbilical tissue-derived cells (hUTC) if conservative treatments fail, offering a safer alternative to surgery.
- This study involved skeletally mature New Zealand white rabbits where discs were punctured to induce degeneration, followed by injections of hUTC with or without a hydrogel.
- MRI results at 12 weeks showed that while the control group remained healthy, the punctured group exhibited degeneration; however, both the hUTC treatments (with or without carrier) showed significantly less evidence of degeneration compared to the punctured group.
Background Context: Intervertebral disc degeneration (IDD) is a common cause of back pain. Patients who fail conservative management may face the morbidity of surgery. Alternative treatment modalities could have a significant impact on disease progression and patients' quality of life.
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