Identification of the Intracellular Na+ Sensor in Slo2.1 Potassium Channels.

Slo2 potassium channels have a very low open probability under normal physiological conditions, but are readily activated in response to an elevated [Na(+)]i (e.g. during ischemia).

Concerted all-or-none subunit interactions mediate slow deactivation of human ether-à-go-go-related gene K+ channels.

During the repolarization phase of a cardiac action potential, hERG1 K(+) channels rapidly recover from an inactivated state then slowly deactivate to a closed state. The resulting resurgence of outward current terminates the plateau phase and is thus a key regulator of action potential duration of cardiomyocytes. The intracellular N-terminal domain of the hERG1 subunit is required for slow deactivation of the channel as its removal accelerates deactivation 10-fold.

Assessment of soybean injury from glyphosate using airborne multispectral remote sensing.

Background: Glyphosate drift onto off-target sensitive crops can reduce growth and yield and is of great concern to growers and pesticide applicators. Detection of herbicide injury using biological responses is tedious, so more convenient and rapid detection methods are needed. The objective of this research was to determine the effects of glyphosate on biological responses of non-glyphosate-resistant (non-GR) soybean and to correlate vegetation indices (VIs) derived from aerial multispectral imagery.

Glyphosate-resistant and glyphosate-susceptible Palmer amaranth (Amaranthus palmeri S. Wats.): hyperspectral reflectance properties of plants and potential for classification.

Background: Palmer amaranth (Amaranthus palmeri S. Wats.) is a troublesome agronomic weed in the southern United States, and several populations have evolved resistance to glyphosate.

Mechanistic insight into human ether-à-go-go-related gene (hERG) K+ channel deactivation gating from the solution structure of the EAG domain.

Human ether-à-go-go-related gene (hERG) K(+) channels have a critical role in cardiac repolarization. hERG channels close (deactivate) very slowly, and this is vital for regulating the time course and amplitude of repolarizing current during the cardiac action potential. Accelerated deactivation is one mechanism by which inherited mutations cause long QT syndrome and potentially lethal arrhythmias.

Biological responses to glyphosate drift from aerial application in non-glyphosate-resistant corn.

Background: Glyphosate drift from aerial application onto susceptible crops is inevitable, yet the biological responses to glyphosate drift in crops are not well characterized. The objectives of this research were to determine the effects of glyphosate drift from a single aerial application (18.3 m swath, 866 g AE ha(-1)) on corn injury, chlorophyll content, shikimate level, plant height and shoot dry weight in non-glyphosate-resistant (non-GR) corn.

Agronomic and environmental implications of enhanced s-triazine degradation.

Novel catabolic pathways enabling rapid detoxification of s-triazine herbicides have been elucidated and detected at a growing number of locations. The genes responsible for s-triazine mineralization, i.e.