Publications by authors named "Steven J Solar"
Robertsonian chromosomes are a type of variant chromosome found commonly in nature. Present in one in 800 humans, these chromosomes can underlie infertility, trisomies, and increased cancer incidence. Recognized cytogenetically for more than a century, their origins have remained mysterious.
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- The study presents detailed genomes of six ape species, achieving high accuracy and complete sequencing of all their chromosomes.
- It addresses complex genomic regions, leading to enhanced understanding of evolutionary relationships among these species.
- The findings will serve as a crucial resource for future research on human evolution and our closest ape relatives.
Article Synopsis
- Apes have two sex chromosomes: the essential Y chromosome for male reproduction and the X chromosome necessary for both reproduction and cognition, with differences in mating patterns affecting their function.
- Studying these chromosomes is challenging due to their repetitive structures, but researchers created gapless assemblies for five great apes and one lesser ape to explore their evolutionary complexities.
- The Y chromosomes are highly variable and undergo significant changes compared to the more stable X chromosomes, and this research can provide insights into human evolution and aid in the conservation of endangered ape species.
. We describe a case of canine Descemet's stripping endothelial keratoplasty (DSEK) using an open-source canine tissue delivery device. .
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- Apes have two main sex chromosomes, X and Y, where Y is crucial for male reproduction and its deletions can lead to infertility, while X is important for both reproduction and brain function.
- Recent advancements in genomic techniques helped researchers create complete structures of the X and Y chromosomes for multiple great ape species, allowing them to explore their evolutionary complexities.
- Findings indicate that Y chromosomes are highly variable and undergo rapid changes due to unique genetic regions and transposable elements, while X chromosomes are more stable, highlighting differing evolutionary paths among great ape species.
Objective: To assess feasibility and compare the effects of 96-hour shipment of Descemet membrane endothelial keratoplasty (DMEK) grafts as a scroll or a tri-fold on cell viability.
Methods And Analysis: DMEK grafts were prepared at the Rocky Mountain Lions Eye Bank. Twenty pre-stripped DMEK grafts, paired from 10 donors, were either tri-folded in an endothelium-in configuration using microforceps and loaded into a plastic Treyetech cartridge, or suctioned in a scrolled endothelium-out configuration into a modified Jones Tube.
Purpose: The trifolded, endothelium-in approach to Descemet membrane endothelial keratoplasty (DMEK) facilitates tissue insertion into the anterior chamber. We hypothesized that preloading the trifolded donor grafts in a cartridge for 48 hours before insertion would induce biomechanical changes that decrease their scrolling tendency compared with those loaded immediately before insertion.
Methods: Ten Descemet membrane donor grafts, peeled and cut to 8.