Spontaneous growth hormone secretory characteristics in children with partial growth hormone insensitivity.

Objective: To investigate the characteristics of spontaneous GH secretion in four male children with short stature due to partial GH insensitivity. Their molecular defect consists of inclusion of a mutant intronic pseudoexon in the region of the GH receptor involved in homodimerization.

Subjects: The subjects were two pairs of brothers who were first cousins, aged 10.