An 8-week open-label trial of a 6-day course of mifepristone for the treatment of psychotic depression.

Objective: Several investigations suggest that mifepristone leads to the rapid amelioration of psychotic depression. However, these studies were of short duration (1 week or less) and included subjects who were taking other psychotropic medications. The goals of this study were to extend these findings by conducting an 8-week trial of mifepristone for subjects with psychotic depression who were taking no concomitant psychiatric medications.

Sertraline as monotherapy in the treatment of psychotic and nonpsychotic depression.

Background: Previous studies suggest that selective serotonin reuptake inhibitors (SSRIs) are effective when used alone in the treatment of unipolar depression with psychotic features. The purpose of the present study was to examine the response to sertraline for patients with and without psychotic features using standard criteria such as recovery and remission.

Method: An 8-week open-label trial of sertraline in depressed inpatients was conducted.