Specific receptor for angiotensinogen on human renal cells.

Background: We recently demonstrated the existence of an angiotensinogen (AGT) receptor on placental cells. It has been established that there is a tissue-specific renin-angiotensin system (RAS) in the human kidney. This study focused on whether human renal proximal tubule epithelial cells possessed an AGT receptor.

Detection of a receptor for angiotensinogen on placental cells.

Background: Current evidence indicates that there may be a tissue-specific renin-angiotensin system (RAS) in the human placenta. To better define the placental RAS, this study sought to determine whether placental derived cells possessed a receptor for angiotensinogen (AGT), a rate limiting component of the RAS.

Methods: A human placenta-derived cell line, CRL-7548, a highly purified AGT and iodine-125-labeled angiotensinogen ((125)I-AGT) were used in this study.