Publications by authors named "Steven J Humphreys"
Front Cardiovasc Med
April 2023
Article Synopsis
- SERPINs (serine protease inhibitors) utilize conformational changes to effectively inhibit target enzymes, playing a crucial role in regulating complex physiological processes like haemostasis and inflammation.
- Key SERPINs, including α2-antiplasmin and C1-inhibitor, are involved in the fibrinolytic system; elevated levels are linked to conditions such as obesity and hypertension, while deficiencies correlate with bleeding disorders.
- Recent research highlights SERPINs' impact on the immune response and conditions like sepsis and COVID-19, suggesting they may serve as biomarkers for disease progression and targets for new therapies in thromboinflammatory diseases.
