Genetic loci linked to pituitary-thyroid axis set points: a genome-wide scan of a large twin cohort.

Objective: Previous studies have shown that circulating concentrations of TSH, free T4, and free T3 are genetically regulated, but the genes responsible remain largely unknown. The aim of this study was to identify genetic loci associated with these parameters.

Design: We performed a multipoint, nonparametric genome-wide linkage scan of 613 female dizygotic twin pairs.