Publications by authors named "Steven Falchuk"
Article Synopsis
- The study examined the health-related quality of life (HRQL) and fatigue levels in brain cancer survivors using donepezil compared to a placebo after radiation therapy.
- Out of 198 patients, those with more severe baseline cognitive symptoms experienced improvements in emotional and social well-being when treated with donepezil at 12 weeks, while those with milder symptoms reported decreased functional well-being and increased fatigue.
- Findings suggest that donepezil may be more beneficial for patients with greater cognitive complaints, indicating that future treatments should focus on this group to maximize benefits and minimize adverse effects.
Purpose: Neurotoxic effects of brain irradiation include cognitive impairment in 50% to 90% of patients. Prior studies have suggested that donepezil, a neurotransmitter modulator, may improve cognitive function.
Patients And Methods: A total of 198 adult brain tumor survivors ≥ 6 months after partial- or whole-brain irradiation were randomly assigned to receive a single daily dose (5 mg for 6 weeks, 10 mg for 18 weeks) of donepezil or placebo.