Ksp1 is an autophagic receptor protein for the Snx4-assisted autophagy of Ssn2/Med13.

Ksp1 is a casein II-like kinase whose activity prevents aberrant macroautophagy/autophagy induction in nutrient-rich conditions in yeast. Here, we describe a kinase-independent role of Ksp1 as a novel autophagic receptor protein for Ssn2/Med13, a known cargo of Snx4-assisted autophagy of transcription factors. In this pathway, a subset of conserved transcriptional regulators, Ssn2/Med13, Rim15, and Msn2, are selectively targeted for vacuolar proteolysis following nitrogen starvation, assisted by the sorting nexin heterodimer Snx4-Atg20.

Cyclin C-Cdk8 Kinase Phosphorylation of Rim15 Prevents the Aberrant Activation of Stress Response Genes.

Cells facing adverse environmental cues respond by inducing signal transduction pathways resulting in transcriptional reprograming. In the budding yeast , nutrient deprivation stimulates stress response gene (SRG) transcription critical for entry into either quiescence or gametogenesis depending on the cell type. The induction of a subset of SRGs require nuclear translocation of the conserved serine-threonine kinase Rim15.

Comparison of Cone-beam Computed Tomography and Multi-slice Spiral Computed Tomography Bone Density Measurements in the Maxilla and Mandible.

Unlabelled: The purpose of this study was to compare cone-beam computer tomography (CBCT) and multi-slice spiral computed tomography (MSCT) bone density measurements in the maxilla and mandible to determine whether any discrepancies between imaging modalities exist.

Material & Methods: 33 sets of CBCT and MSCT scans were evaluated using Simplant software. Density measurements were made in eight regions of interest on each scan and were compared and analyzed.