Case Report: Unmasked Inherited Dysfibrinogenemia After Everolimus Therapy.

A previously hemostatically asymptomatic patient with common variable hypogammaglobulinemia was given everolimus to prevent growth of her liver. Within several months, the patient developed a severe bleeding disorder. The bleeding was due to fibrin polymerization defect that upon sequencing was shown to be dysfibrinogenemia Krakow III.

Ponatinib treatment promotes arterial thrombosis and hyperactive platelets.

Ponatinib therapy heightens arterial thrombosis and platelet reactivity. Concurrent pioglitazone treatment reverses heightened thrombosis risk and platelet reactivity induced by ponatinib.

Relationship between intraoperative serum lactate and hemoglobin levels on postoperative renal function in patients undergoing elective cardiac surgery.

Background And Aim: We examined the relationship between serum lactate and hemoglobin levels on renal function and postoperative outcome in low-risk elective coronary artery bypass graft (CABG) patients.

Methods: Intraoperative hemoglobin and lactate levels were measured in elective isolated CABG patients. Patients with renal dysfunction (baseline creatinine>2 mg/dL) were excluded.

Computer-aided diagnosis via model-based shape analysis: automated classification of wall motion abnormalities in echocardiograms.

Rationale And Objective: Shape analysis of endocardial contour sequences from echocardiograms can provide classification of wall motion abnormalities (WMA).

Materials And Methods: We previously reported on active appearance motion models (AAMM) for automated detection of endocardial contours in sequences of echocardiograms. The shape analysis of AAMM renders eigenvariations of shape/motion, including typical normal and pathologic endocardial contraction patterns.

Biochemical and clinical aspects of the human flavin-containing monooxygenase form 3 (FMO3) related to trimethylaminuria.

Trimethylaminuria is a rare metabolic disorder that is associated with abnormal amounts of the dietary-derived trimethylamine. Excess unmetabolized trimethylamine in the urine, sweat and other body secretions confers a strong, foul body odor that can affect the individual's ability to work or engage in social activities. This review summarizes the biochemical aspects of the condition and the classification of the disorder into: 1) primary genetic form, 2) acquired form, 3) childhood forms, 4) transient form associated with menstruation, 5) precursor overload and 6) disease states.

Automatic segmentation of echocardiographic sequences by active appearance motion models.

A novel extension of active appearance models (AAMs) for automated border detection in echocardiographic image sequences is reported. The active appearance motion model (AAMM) technique allows fully automated robust and time-continuous delineation of left ventricular (LV) endocardial contours over the full heart cycle with good results. Nonlinear intensity normalization was developed and employed to accommodate ultrasound-specific intensity distributions.

3-D active appearance models: segmentation of cardiac MR and ultrasound images.

A model-based method for three-dimensional image segmentation was developed and its performance assessed in segmentation of volumetric cardiac magnetic resonance (MR) images and echocardiographic temporal image sequences. Comprehensive design of a three-dimensional (3-D) active appearance model (AAM) is reported for the first time as an involved extension of the AAM framework introduced by Cootes et al. The model's behavior is learned from manually traced segmentation examples during an automated training stage.