Effect of a new local anesthetic buffering device on pain reduction during nerve block injections.

The purpose of this double-blind, split-mouth, randomized human clinical study was to evaluate the effectiveness of a new sodium bicarbonate local anesthetic buffering device (Onset) in reducing pain associated with dental injections. Twenty patients were given bilateral inferior alveolar (IA) and long buccal (LB) nerve block injections and asked to quantify the pain experienced during injection on a visual analog scale (0, no pain; 10, worst possible pain). One side of the mouth received standard-of-care injections of 2% lidocaine with 1:100,000 epinephrine.

An in vitro comparison of antimicrobial toothbrushes.

The purpose of this study was to determine the efficacy of toothbrushes that advertise self-disinfecting, antimicrobial properties due to the inclusion of silver nanoparticles or chlorhexidine in the bristles. Three different types of toothbrushes-silver nanoparticle, chlorhexidine-coated, and a control-were submerged in suspensions of Streptococcus mutans and Candida albicans. At designated times postinoculation, organisms were removed from the toothbrush heads, then serially diluted, plated, and incubated.

Effects of a vibratory device on pain from anesthetic injections.

Background: A randomized block, split-mouth design was used to determine the effectiveness of a vibratory device with topical anesthetic compared to topical anesthetic only in reducing the pain experienced during an inferior alveolar nerve block.

Methods: Twenty participants each received two inferior alveolar injections with a 5-minute interval between injections, one with topical anesthetic and one with topical anesthetic and a vibratory device. Each injection included a 2-minute application of topical anesthetic gel at the injection site.

Periodontal wound healing with and without platelet-rich plasma: histologic observations and assessment of flap tensile strength.

Background: Platelet-rich plasma (PRP) has been promoted as a surgical adjunct to enhance hard and soft tissue wound healing. Although anecdotally reported to be of value, the results of controlled studies examining the added effects of PRP on surgical procedures have been mixed. The purpose of this study was to test the effect of PRP on flap strength at various post-surgical time points in a minipig animal model.

Human gingival fibroblast integrin subunit expression on titanium implant surfaces.

Background: Implant surface characteristics have been shown to modify cell behavior and regulate integrin expression. Integrin expression and resultant integrin-mediated cellular activity are essential components of tissue healing and homeostasis. Although both osseous and soft tissue healing around dental implants are critical to clinical success, there is limited information available on the effect of implant surfaces on integrin expression in soft tissues.