Safety and efficacy of intravesical chemotherapy and hyperthermia in the bladder: results of a porcine study.

Background: Hyperthermia (heating to 43 °C) activates the innate immune system and improves bladder cancer chemosensitivity.

Objective: To evaluate the tissue penetration and safety of convective hyperthermia combined with intravesical mitomycin C (MMC) pharmacokinetics in live porcine bladder models using the Combat bladder recirculation system (BRS).

Methods: Forty 60 kg-female swine were anesthetized and catheterized with a 3-way, 16 F catheter.

Heat-targeted drug delivery: A promising approach for organsparing treatment of bladder cancer.THERMODOX®.

Disease recurrence and progression remain as significant challenges for the management of non-muscle invasive bladder cancer (NMIBC). In recent years, novel drugs and delivery systems have been investigated as strategies to reduce recurrence, progression and mortality. In this review, we focus on the role of intravesical hyperthermic chemotherapy and discuss a novel approach involving a heat-activated drug delivery system (ThermoDox®) that enables local accumulation of systemic chemotherapy.

Vinflunine for the treatment of advanced or metastatic transitional cell carcinoma of the urothelial tract: an evidence-based review of safety, efficacy, and place in therapy.

Background: A systematic review and meta-analysis of the use of systemic vinflunine (VIN) in the treatment of urothelial carcinoma (UC) was performed to evaluate its efficacy based on current available clinical data.

Methods: This review was prospectively registered at the International Prospective Register of Systematic Reviews, PROSPERO (registration CRD42016049294). Electronic databases including MEDLINE, Embase, Cochrane Central Register of Controlled Trials, and Web of Science were searched through December 2016.