β2GPI exerts an anti-obesity effect in female mice by inhibiting lipogenesis and promoting lipolysis.

In humans, males compared to females have increased visceral adipose tissue which contributes to their increased risk of early death. Mice display analogous sexual diamorphism whereby females are protected from weight gain when fed a high fat diet compared to males. A role has recently been reported for β-glycoprotein I, an abundant plasma protein, in healthy leanness in humans.