Repeated lipopolysaccharide exposure modifies immune and sickness behaviour response in an animal model of chronic inflammation.

Repeated lipopolysaccharide exposure is often used in longitudinal preclinical models of depression. However, the potential phenotypic differences from acute depression-mimicking effects are rarely described. This study compared chronic lipopolysaccharide administration of doses previously used in depression research to a new mode of escalating dose injections.

Compartment syndrome after low molecular weight heparin following lower limb blunt trauma: lessons for outpatient deep vein thrombosis protocols.

A fit and well 36-year-old male presented to his general practitioner with a 10-day history of pain and swelling in his right leg following a football injury. He had sustained blunt trauma to the lateral aspect of his right thigh and described it as a "dead leg". A clinical diagnosis of deep vein thrombosis (DVT) was made and the patient was advised to attend the DVT outpatient clinic.

Ultrafast energy transfer between the 3MLCT state of [Ru(II)(dmb)2(bpy-an)]2+ and the covalently appended anthracene.

The time scale for triplet-triplet energy transfer (EnT) between a Ru(II) chromophore and a ligand bound anthracene acceptor in [Ru(II)(dmb)2(bpy-an)]2+ (dmb = 4,4'-dimethyl-2,2-bipyridine; bpy-an = 4-(9-anthrylethylene), 4-methyl-2,2-bipyridine) has been measured using femtosecond transient absorption spectroscopy. The appearance of the anthracene excited state is monitored following photoexcitation to a metal-to-ligand charge transfer (MLCT) state via the pi pi* absorption of the triplet excited state of anthracene. Our time-resolved experiments show the presence of fast, sub-100 ps energy transfer to the anthracene occurring on two characteristic time scales of 23 and 72 ps.

Synthesis and characterization of oligoproline-based molecular assemblies for light harvesting.

Helical oligoproline arrays provide a structurally well-defined environment for building photochemical energy conversion assemblies. The use of solid-phase peptide synthesis (SPPS) to prepare four such arrays, consisting of 16, 17, 18, and 19 amino acid residues, is described here. Each array contains the chromophore [Rub'(2)m](PF(6))(2) (b' = 4,4'-diethylamidocarbonyl-2,2'-bipyridine; m = 4-methyl-2,2'-dipyridine-4'-carboxylic acid) and the electron transfer donor PTZ (phenothiazine).