Publications by authors named "Steve Sigelman"
Background: Asthma prevalence and severity have markedly increased with urbanisation, and children in low-income urban centres have among the greatest asthma morbidity. Outdoor air pollution has been associated with adverse respiratory effects in children with asthma. However, the mechanisms by which air pollution exposure exacerbates asthma, and how these mechanisms compare with exacerbations induced by respiratory viruses, are poorly understood.
View Article and Find Full Text PDFRespiratory infections are common precursors to asthma exacerbations in children, but molecular immune responses that determine whether and how an infection causes an exacerbation are poorly understood. By using systems-scale network analysis, we identify repertoires of cellular transcriptional pathways that lead to and underlie distinct patterns of asthma exacerbation. Specifically, in both virus-associated and nonviral exacerbations, we demonstrate a set of core exacerbation modules, among which epithelial-associated SMAD3 signaling is upregulated and lymphocyte response pathways are downregulated early in exacerbation, followed by later upregulation of effector pathways including epidermal growth factor receptor signaling, extracellular matrix production, mucus hypersecretion, and eosinophil activation.
View Article and Find Full Text PDFArticle Synopsis
- Rhinitis is highly prevalent in urban children with asthma, affecting 93.5% of a studied group, with perennial allergic rhinitis being the most common and severe type.
- The study analyzed 619 children and found that many remained symptomatic despite treatment, especially those with difficult-to-control asthma.
- The findings suggest that rhinitis and asthma are closely linked, representing two manifestations of the same underlying airway condition.
Background: Asthma was the most common comorbidity of patients hospitalized with 2009 H1N1 influenza.
Objective: We sought to assess the immunogenicity and safety of an unadjuvanted, inactivated 2009 H1N1 vaccine in patients with severe versus mild-to-moderate asthma.
Methods: We conducted an open-label study involving 390 participants (age, 12-79 years) enrolled in October-November 2009.