Publications by authors named "Steve Settle"
Osteoarthritis (OA) is a degenerative joint disease that has no FDA-approved treatment. The current standard of care does not address the regeneration of the damaged cartilage. Human growth hormone (hGH) is part of the insulin-like growth factor (IGF)-1 axis.
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- - Mitogen-activated protein kinase (MAPK) pathways, particularly p38 MAPK, play a crucial role in joint destruction in rheumatoid arthritis by influencing inflammatory cytokine production and function.
- - The study found that a new p38 inhibitor (SC-409) can block osteoclast development induced by RANKL and TNF-alpha, and it also reduced joint swelling and bone destruction in a rat model of arthritis.
- - SC-409 works by inhibiting the activation of certain transcription factors and cytokine expressions linked to p38, suggesting that therapies targeting p38 might help prevent bone loss in rheumatoid arthritis patients.