Thirty-year analysis of a colonoscopic surveillance program for neoplasia in ulcerative colitis.

Background & Aims: The value of colonoscopic surveillance for neoplasia in long-standing extensive ulcerative colitis remains controversial. This study reports on prospectively collected data from a surveillance program over a 30-year period.

Methods: Data were obtained from the prospective surveillance database, medical records, colonoscopy, and histology reports.

Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis.

Background & Aims: Patients with ulcerative colitis are at increased risk of colorectal cancer. It is widely believed that this is secondary to colonic inflammation. However, the severity of colonic inflammation has never been shown to be a risk factor.