Publications by authors named "Steve P Millard"

The antisaccade task is a widely used technique to measure failure of inhibition, an important cause of cognitive and clinical abnormalities found in schizophrenia. Although antisaccade performance, which reflects the ability to inhibit prepotent responses, is a putative schizophrenia endophenotype, researchers have not consistently reported the expected differences between first-degree relatives and comparison groups. Schizophrenia participants (n=219) from the large Consortium on the Genetics of Schizophrenia (COGS) sample (n=1078) demonstrated significant deficits on an overlap version of the antisaccade task compared to their first-degree relatives (n=443) and community comparison subjects (CCS; n=416).

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Article Synopsis
  • Denufosol tetrasodium is a P2Y(2) agonist that promotes lung hydration and mucus clearance, aimed at treating cystic fibrosis.
  • A phase 2 clinical trial was conducted with 89 patients over 28 days to compare denufosol treatment with a placebo.
  • Results showed that denufosol was well tolerated, with significant improvements in lung function metrics compared to placebo, suggesting it may benefit patients with mild cystic fibrosis.
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