Publications by authors named "Steve P Jackson"
Article Synopsis
- - A study estimates that 20% of men in the UK have detectable loss of chromosome Y (LOY) in their white blood cells, a common genetic phenomenon.
- - Researchers identified 156 genes associated with LOY, linking them to cell-cycle regulation, cancer risk, and tumor growth, affirming LOY's relevance to health issues beyond blood disorders.
- - The findings suggest that LOY may indicate genomic instability in other tissues and emphasize the importance of understanding clonal mosaicism for insights into cancer and age-related diseases. !*
The Y chromosome is frequently lost in hematopoietic cells, which represents the most common somatic alteration in men. However, the mechanisms that regulate mosaic loss of chromosome Y (mLOY), and its clinical relevance, are unknown. We used genotype-array-intensity data and sequence reads from 85,542 men to identify 19 genomic regions (P < 5 × 10) that are associated with mLOY.
View Article and Find Full Text PDF