Publications by authors named "Steve P Cobbold"
J Biol Chem
December 2022
Article Synopsis
- The study investigates how the surrounding boundary lipids affect the behavior of integral membrane proteins, specifically focusing on the Lck kinase and its regulation by the CD45 phosphatase.
- Using advanced techniques like super-resolution microscopy and flow cytometry, researchers found that Lck is generated at the plasma membrane and maintained in a dynamic balance with its unphosphorylated form through a process called trans-autophosphorylation.
- The findings suggest that fluctuations in the lipid bilayer rather than previously assumed phase-separated domains are key to understanding Lck formation and its interactions with CD45, highlighting the role of boundary lipids in this process.
