Publications by authors named "Steve Nick"
BMC Res Notes
November 2023
Article Synopsis
- Doxorubicin (DOX) is an effective chemotherapy drug but can cause harmful heart issues, leading to cardiomyopathy, which limits its use.
- The study focused on how DOX affects the cardiac extracellular matrix (ECM) and found that it down-regulates key ECM-related genes and alters the fibroblast proteome.
- Additionally, DOX treatment increases collagen production in cardiac fibroblasts but does not significantly change collagen organization or glycoprotein levels.
