Publications by authors named "Steve Frey"
Minipig skin is one of the most widely used non-rodent animal skin models for dermatological research. A thorough characterization of minipig skin is essential for gaining deeper understanding of its structural and functional similarities with human skin. In this study, three-dimensional (3-D) images of minipig skin was obtained non-invasively using a multimodal optical imaging system capable of acquiring two-photon excited fluorescence (TPEF) and fluorescence lifetime imaging microscopy (FLIM) images simultaneously.
View Article and Find Full Text PDFBackground: An Investigator Global Assessment (IGA) is recommended by health agencies for drug registration in atopic dermatitis (AD). Current IGA scales lack standardization.
Objectives: To develop an IGA scale, training module, and clinical certification examination for use in AD trials; establish content validity; and assess reliability.
Article Synopsis
- The study investigated the safety and maximum-tolerated dose (MTD) of a selective EZH2 inhibitor, GSK2816126, in patients with solid tumors or B-cell lymphomas who had no alternative treatment options.
- Forty-one patients participated, experiencing common side effects like fatigue and nausea, with a MTD set at 2,400 mg due to elevated liver enzymes noted at higher doses.
- While some patients showed stable disease or partial responses, the overall anticancer efficacy was limited, likely due to the short half-life of the drug affecting its effectiveness.