Publications by authors named "Steve Cobbold"
Article Synopsis
- The study investigates how the surrounding boundary lipids affect the behavior of integral membrane proteins, specifically focusing on the Lck kinase and its regulation by the CD45 phosphatase.
- Using advanced techniques like super-resolution microscopy and flow cytometry, researchers found that Lck is generated at the plasma membrane and maintained in a dynamic balance with its unphosphorylated form through a process called trans-autophosphorylation.
- The findings suggest that fluctuations in the lipid bilayer rather than previously assumed phase-separated domains are key to understanding Lck formation and its interactions with CD45, highlighting the role of boundary lipids in this process.
DCs play a central role in the development of innate and adaptive immunity but also in the induction and maintenance of immune tolerance. Identification of factors that govern DC activation, their maturation state, and their capacity to induce proinflammatory or tolerogeneic responses therefore represents a crucial aim of research. We previously identified a new molecule, Tmem176B (which we named TORID initially), as highly expressed in a model of allograft tolerance in the rat.
View Article and Find Full Text PDFBackground: The cross-talk between pathogenic T lymphocytes and regulatory T cells (Tregs) plays a major role in the progression of autoimmune diseases. Our objective is to identify molecules and/or pathways involved in this interaction and representing potential targets for innovative therapies. Glucocorticoid-induced tumor necrosis factor receptor (GITR) and its ligand are key players in the T effector/Treg interaction.
View Article and Find Full Text PDF